B lymphocytes contribute to autoimmune disease pathogenesis: Current trends and clinical implications

Joseph Tuscano, Geoffrey S. Harris, Thomas F. Tedder

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Abnormal B lymphocytes influence the pathogenesis of many autoimmune diseases, in addition to serving as the origin of pathogenic autoantibodies. Although aberrant B cell function and autoimmunity have complex polygenic origins, recent studies in mouse models of autoimmune diseases have revealed overlapping defects in signal transduction pathways that alter B cell survival or activation, and lead to an autoimmune phenotype. Discovery of these important signaling pathways in mice has lead to an intense search for B cell abnormalities that correlate with autoimmune diseases in humans. This search has identified potential targets for therapeutic intervention that are the focus of planned and ongoing human clinical trials. This promises an arsenal of highly targeted, less toxic therapies focused on restoring normal B cell function that will eliminate pathogenic autoantibodies and replace the current use of immunosuppressive drugs.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalAutoimmunity Reviews
Volume2
Issue number2
DOIs
StatePublished - Mar 2003

Keywords

  • B lymphocyte
  • CD19
  • CD20
  • CD22
  • Immunotherapy
  • Signal transduction

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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