B cells are selectively associated with thymic cortical but not medullary pathology in NZB mice

Nobuyoshi Taguchi, Yoshiko Hashimoto, Tom Hsu, Aftab A. Ansari, Len Shultz, Kenneth Dorshkind, Susumu Ikehara, Mitsuru Naiki, M. Eric Gershwin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Abnormal expansion of autoantibody-synthesizing B cells and self-reactive T cells, which most likely escape negative selection within the thymus, have both been characterized and reasoned to play a role in the pathogenesis of autoimmunity in NZB mice. Support for this thesis has been our observation that NZB mice have severe cortical and medullary thymic microarchitectural defects. As a means to dissect the roles of T and B cells in the induction of such abnormalities, B cell-deficient NZB mice were bred by backcrossing the Igh6null allele on to the NZB background (NZB-μMT mice). Such mice showed undetectable levels of autoantibodies. NZB-μMT mice, as compared to wild-type NZB mice, had lower absolute numbers of CD4+ T cells. Furthermore, thymic abnormalities in NZB-μMT mice were restricted to the medulla. These data suggest that, while B cells may play a role in thymic cortical abnormalities, the medullary abnormalities are induced by other mechanisms.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalJournal of Autoimmunity
Volume16
Issue number4
DOIs
StatePublished - 2001

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Keywords

  • Autoimmunity
  • B lymphocytes
  • Rodent
  • Stromal cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Taguchi, N., Hashimoto, Y., Hsu, T., Ansari, A. A., Shultz, L., Dorshkind, K., Ikehara, S., Naiki, M., & Gershwin, M. E. (2001). B cells are selectively associated with thymic cortical but not medullary pathology in NZB mice. Journal of Autoimmunity, 16(4), 393-400. https://doi.org/10.1006/jaut.2001.0515