B-1 cell responses to infections

Fauna L. Smith, Nicole Baumgarth

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

B-1 cells represent an innate-like early-developing B cell population, whose existence as an independent lymphocyte subset has been questioned in the past. Recent molecular and lineage tracing studies have not only confirmed their unique origins and differentiation paths, they have also provided a rationale for their distinctive functionalities compared to conventional B cells. This review summarizes our current understanding of B-1 cell development, and the activation events that regulate B-1 cell responses to self and foreign antigens. We discuss the unresolved question to what extent BCR engagement, that is, antigen-specificity versus innate signaling contributes to B-1 cell's participation in tissue homeostasis and immune defense as providers of ‘natural’ and antigen-induced antibody responses, and as cytokine-producing immune regulators.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalCurrent Opinion in Immunology
Volume57
DOIs
StatePublished - Apr 1 2019

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Infection
B-Lymphocytes
Antigens
Lymphocyte Subsets
Autoantigens
Antibody Formation
Homeostasis
Cytokines
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

B-1 cell responses to infections. / Smith, Fauna L.; Baumgarth, Nicole.

In: Current Opinion in Immunology, Vol. 57, 01.04.2019, p. 23-31.

Research output: Contribution to journalReview article

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