B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM. Natural IgM is constitutively produced, even in the absence of microbiota, and fulfills many distinct functions in tissue homeostasis and host defense. B-1 cells also respond with IgM production to innate signals and pathogen exposure, while maintaining steady-state levels natural IgM. Thus, within the B-1 cell pool, cells of distinct and heterogeneous functionality must exist to facilitate these different functions. This review considers three factors that may contribute to this heterogeneity: first, developmental differences regarding the origins of the precursors, second, tissue-specific signals that may differentially affect B-1 cells in the tissue compartments, and finally responsiveness to self-antigens as well as innate and antigen-specific signals. All three are likely to shape the repertoire and responsiveness of B-1 cells to homeostatic- and antigen-induced signals and thus contribute to the functional heterogeneity among these innate-like B cells.

Original languageEnglish (US)
Article number324
JournalFrontiers in Immunology
Volume7
Issue numberSEP
DOIs
StatePublished - Sep 9 2016

Fingerprint

Immunoglobulin M
Antigens
B-Lymphocytes
B-Lymphocyte Subsets
Microbiota
Autoantigens
Homeostasis
Phenotype

Keywords

  • B cell development
  • B-1 cells
  • Immune regulation
  • Innate-like lymphocytes
  • Natural IgM

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production. / Baumgarth, Nicole.

In: Frontiers in Immunology, Vol. 7, No. SEP, 324, 09.09.2016.

Research output: Contribution to journalReview article

@article{14eaa1e1d8934b4782d387c0afcc7a6e,
title = "B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production",
abstract = "A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced {"}natural{"} IgM. Natural IgM is constitutively produced, even in the absence of microbiota, and fulfills many distinct functions in tissue homeostasis and host defense. B-1 cells also respond with IgM production to innate signals and pathogen exposure, while maintaining steady-state levels natural IgM. Thus, within the B-1 cell pool, cells of distinct and heterogeneous functionality must exist to facilitate these different functions. This review considers three factors that may contribute to this heterogeneity: first, developmental differences regarding the origins of the precursors, second, tissue-specific signals that may differentially affect B-1 cells in the tissue compartments, and finally responsiveness to self-antigens as well as innate and antigen-specific signals. All three are likely to shape the repertoire and responsiveness of B-1 cells to homeostatic- and antigen-induced signals and thus contribute to the functional heterogeneity among these innate-like B cells.",
keywords = "B cell development, B-1 cells, Immune regulation, Innate-like lymphocytes, Natural IgM",
author = "Nicole Baumgarth",
year = "2016",
month = "9",
day = "9",
doi = "10.3389/fimmu.2016.00324",
language = "English (US)",
volume = "7",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "SEP",

}

TY - JOUR

T1 - B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production

AU - Baumgarth, Nicole

PY - 2016/9/9

Y1 - 2016/9/9

N2 - A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM. Natural IgM is constitutively produced, even in the absence of microbiota, and fulfills many distinct functions in tissue homeostasis and host defense. B-1 cells also respond with IgM production to innate signals and pathogen exposure, while maintaining steady-state levels natural IgM. Thus, within the B-1 cell pool, cells of distinct and heterogeneous functionality must exist to facilitate these different functions. This review considers three factors that may contribute to this heterogeneity: first, developmental differences regarding the origins of the precursors, second, tissue-specific signals that may differentially affect B-1 cells in the tissue compartments, and finally responsiveness to self-antigens as well as innate and antigen-specific signals. All three are likely to shape the repertoire and responsiveness of B-1 cells to homeostatic- and antigen-induced signals and thus contribute to the functional heterogeneity among these innate-like B cells.

AB - A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM. Natural IgM is constitutively produced, even in the absence of microbiota, and fulfills many distinct functions in tissue homeostasis and host defense. B-1 cells also respond with IgM production to innate signals and pathogen exposure, while maintaining steady-state levels natural IgM. Thus, within the B-1 cell pool, cells of distinct and heterogeneous functionality must exist to facilitate these different functions. This review considers three factors that may contribute to this heterogeneity: first, developmental differences regarding the origins of the precursors, second, tissue-specific signals that may differentially affect B-1 cells in the tissue compartments, and finally responsiveness to self-antigens as well as innate and antigen-specific signals. All three are likely to shape the repertoire and responsiveness of B-1 cells to homeostatic- and antigen-induced signals and thus contribute to the functional heterogeneity among these innate-like B cells.

KW - B cell development

KW - B-1 cells

KW - Immune regulation

KW - Innate-like lymphocytes

KW - Natural IgM

UR - http://www.scopus.com/inward/record.url?scp=84992028974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992028974&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2016.00324

DO - 10.3389/fimmu.2016.00324

M3 - Review article

VL - 7

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - SEP

M1 - 324

ER -