George Richard Thompson, Thomas F. Patterson

Research output: Chapter in Book/Report/Conference proceedingChapter


The treatment of invasive aspergillosis remains difficult and until recently only polyenes and itraconazole were viable treatment options. However the development of newer triazoles (voriconazole, posaconazole) has been a welcome addition to the antifungal armamentarium. The proven efficacy of prophylactic posaconazole in high-risk patients, and the use of voriconazole during treatment of invasive aspergillosis have largely replaced amphotericin B and itraconazole use for these indications. Other extended-spectrum triazoles in preclinical development (ravuconazole, isavuconazole, and albaconazole) offer additional pharmacodynamic/pharmacokinetic advantages and will also be reviewed.

Original languageEnglish (US)
Title of host publicationAspergillosis: From Diagnosis to Prevention
PublisherSpringer Netherlands
Number of pages32
ISBN (Print)9789048124084, 9789048124077
StatePublished - 2010
Externally publishedYes


  • Albaconazole
  • Isavuconazole
  • Itraconazole
  • Posaconazole
  • Ravuconazole
  • Triazoles
  • Voriconazole

ASJC Scopus subject areas

  • Medicine(all)


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