Azoles

George Richard Thompson, Thomas F. Patterson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The treatment of invasive aspergillosis remains difficult and until recently only polyenes and itraconazole were viable treatment options. However the development of newer triazoles (voriconazole, posaconazole) has been a welcome addition to the antifungal armamentarium. The proven efficacy of prophylactic posaconazole in high-risk patients, and the use of voriconazole during treatment of invasive aspergillosis have largely replaced amphotericin B and itraconazole use for these indications. Other extended-spectrum triazoles in preclinical development (ravuconazole, isavuconazole, and albaconazole) offer additional pharmacodynamic/pharmacokinetic advantages and will also be reviewed.

Original languageEnglish (US)
Title of host publicationAspergillosis: From Diagnosis to Prevention
PublisherSpringer Netherlands
Pages231-262
Number of pages32
ISBN (Print)9789048124084, 9789048124077
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Albaconazole
  • Isavuconazole
  • Itraconazole
  • Posaconazole
  • Ravuconazole
  • Triazoles
  • Voriconazole

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Thompson, G. R., & Patterson, T. F. (2010). Azoles. In Aspergillosis: From Diagnosis to Prevention (pp. 231-262). Springer Netherlands. https://doi.org/10.1007/978-90-481-2408-4_15