Abstract
Left cervical vagotomy increased NADPH-diaphorase (NADPH-d) histochemical staining in neuronal perikarya of the ipsilateral dorsal motor nucleus of the vagus (dmnX) and the rostral part of the nucleus ambiguus (nAmb). This effect appeared by 2 days, was maximal around 10 days, and declined by 30 days after vagotomy. Light and dark stained perikarya occurred in dmn X ipsilateral to the vagotomy which could not be explained on the basis of the biochemical or transmitter content of these neurons. It is unlikely that the increases of NADPH-d activity resulted from changes in cholinergic transmission since vagotomy is known to decrease cholinergic enzyme function. Since vagotomy increased both the glucose metabolic rate and NADPH-d staining of dmnX and nAmb in these experiments, it is more likely that these effects represent regenerative metabolic responses to axotomy.
Original language | English (US) |
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Pages (from-to) | 417-427 |
Number of pages | 11 |
Journal | Brain Research Bulletin |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - 1987 |
Externally published | Yes |
Keywords
- NADPH-diaphorase Vagus nerve Dorsal motor nucleus of vagus Nucleus ambiguus Vagotomy 2-Deoxyglucose
ASJC Scopus subject areas
- Neuroscience(all)