Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5)

Marina Scarlato; Theodore Xu; Peter Bannerman; Jacqueline Beesley; Usha R. Reddy; Abdolmohammad Rostami; Steven S. Scherer; David E Pleasure

doi:10.1002/jnr.1193

Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5)

Marina Scarlato, Theodore Xu, Peter Bannerman, Jacqueline Beesley, Usha R. Reddy, Abdolmohammad Rostami, Steven S. Scherer, David E Pleasure

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res.

Original language	English (US)
Pages (from-to)	16-22
Number of pages	7
Journal	Journal of Neuroscience Research
Volume	66
Issue number	1
DOIs	https://doi.org/10.1002/jnr.1193
State	Published - Oct 1 2001
Externally published	Yes

Keywords

Axotomy
CAMP
Neuropathy
Wallerian degeneration

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/jnr.1193

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Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5). / Scarlato, Marina; Xu, Theodore; Bannerman, Peter; Beesley, Jacqueline; Reddy, Usha R.; Rostami, Abdolmohammad; Scherer, Steven S.; Pleasure, David E.

In: Journal of Neuroscience Research, Vol. 66, No. 1, 01.10.2001, p. 16-22.

Research output: Contribution to journal › Article › peer-review

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abstract = "We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res.",

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AU - Scarlato, Marina

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AU - Bannerman, Peter

AU - Beesley, Jacqueline

AU - Reddy, Usha R.

AU - Rostami, Abdolmohammad

AU - Scherer, Steven S.

AU - Pleasure, David E

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AB - We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res.

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Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5)

Abstract

Keywords

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