Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5)

Marina Scarlato, Theodore Xu, Peter Bannerman, Jacqueline Beesley, Usha R. Reddy, Abdolmohammad Rostami, Steven S. Scherer, David E Pleasure

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalJournal of Neuroscience Research
Volume66
Issue number1
DOIs
StatePublished - Oct 1 2001
Externally publishedYes

Keywords

  • Axotomy
  • CAMP
  • Neuropathy
  • Wallerian degeneration

ASJC Scopus subject areas

  • Neuroscience(all)

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