Abstract
We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16-22 |
| Number of pages | 7 |
| Journal | Journal of Neuroscience Research |
| Volume | 66 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1 2001 |
| Externally published | Yes |
Keywords
- Axotomy
- CAMP
- Neuropathy
- Wallerian degeneration
ASJC Scopus subject areas
- Neuroscience(all)
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Scarlato, M., Xu, T., Bannerman, P., Beesley, J., Reddy, U. R., Rostami, A., Scherer, S. S., & Pleasure, D. E. (2001). Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5). Journal of Neuroscience Research, 66(1), 16-22. https://doi.org/10.1002/jnr.1193