Axon pruning in the developing vertebrate hippocampus

Regina L. Faulkner, Lawrence K. Low, Hwai-Jong Cheng

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.

Original languageEnglish (US)
Pages (from-to)6-13
Number of pages8
JournalDevelopmental Neuroscience
Volume29
Issue number1-2
DOIs
StatePublished - Dec 2006

Fingerprint

Neuronal Plasticity
Vertebrates
Hippocampus
Central Nervous System

Keywords

  • Axon pruning
  • Axon retraction
  • Hippocampus
  • Mossy fiber
  • Plexin
  • Semaphorin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Axon pruning in the developing vertebrate hippocampus. / Faulkner, Regina L.; Low, Lawrence K.; Cheng, Hwai-Jong.

In: Developmental Neuroscience, Vol. 29, No. 1-2, 12.2006, p. 6-13.

Research output: Contribution to journalArticle

Faulkner, RL, Low, LK & Cheng, H-J 2006, 'Axon pruning in the developing vertebrate hippocampus', Developmental Neuroscience, vol. 29, no. 1-2, pp. 6-13. https://doi.org/10.1159/000096207
Faulkner, Regina L. ; Low, Lawrence K. ; Cheng, Hwai-Jong. / Axon pruning in the developing vertebrate hippocampus. In: Developmental Neuroscience. 2006 ; Vol. 29, No. 1-2. pp. 6-13.
@article{2042d47be36b44de8cbf6fdd60bf3dcc,
title = "Axon pruning in the developing vertebrate hippocampus",
abstract = "During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.",
keywords = "Axon pruning, Axon retraction, Hippocampus, Mossy fiber, Plexin, Semaphorin",
author = "Faulkner, {Regina L.} and Low, {Lawrence K.} and Hwai-Jong Cheng",
year = "2006",
month = "12",
doi = "10.1159/000096207",
language = "English (US)",
volume = "29",
pages = "6--13",
journal = "Developmental Neuroscience",
issn = "0378-5866",
publisher = "S. Karger AG",
number = "1-2",

}

TY - JOUR

T1 - Axon pruning in the developing vertebrate hippocampus

AU - Faulkner, Regina L.

AU - Low, Lawrence K.

AU - Cheng, Hwai-Jong

PY - 2006/12

Y1 - 2006/12

N2 - During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.

AB - During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.

KW - Axon pruning

KW - Axon retraction

KW - Hippocampus

KW - Mossy fiber

KW - Plexin

KW - Semaphorin

UR - http://www.scopus.com/inward/record.url?scp=33845580809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845580809&partnerID=8YFLogxK

U2 - 10.1159/000096207

DO - 10.1159/000096207

M3 - Article

VL - 29

SP - 6

EP - 13

JO - Developmental Neuroscience

JF - Developmental Neuroscience

SN - 0378-5866

IS - 1-2

ER -