Axium MicroFX coil for the completing endovascular aneurysm surgery study (ACCESS)

A prospective evaluation of the safety and durability of axium MicroFX PGLA coils

Ben Waldau, K. M. Fargen, W. J. Mack, N. M. Wilson, A. Khaldi, B. L. Hoh, J. Mocco

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recanalization of previously coiled aneurysms remains a major drawback of endovascular aneurysm therapy. We performed a prospective single arm trial to provide early initial data regarding the safety and angiographic durability of a new coil technology, the Axium MicroFX Polyglycolic/polylactic acid (PGLA) coil, which was designed to lower recanalization rates. Fifteen patients (16 aneurysms) were prospectively enrolled. Demographic and peri-procedural data were collected. Angiographic images of the initial coil embolization and three to six month follow-up angiographic images underwent blinded evaluation. Seven (47%) SAH and eight (53%) elective patients were enrolled. Blinded evaluation of the initial embolization demonstrated that 5/16 (31%) aneurysms achieved Raymond grade 1, 5/16 (31%) grade 2 and 6/16 (38%) grade 3. Three to six month angiography was obtained in 12/15 patients (80%); two patients expired (1 SAH, 1 elective) and one was lost to follow-up (SAH). All patients who underwent follow-up angiography had a mRS ≤1. Blinded evaluation of embolization demonstrated 7/13 aneurysms (54%) improved in Raymond grading, five (38%) were stable and one aneurysm (8%) worsened. One patient developed an asymptomatic peri-aneurysmal parent vessel stenosis. Axium MicroFX coils appear to be safe, though the small number of patients in this series obviates comparative analysis with other series. Further studies are needed with more patients to compare the angiographic durability of Axium MicroFX coils to other coils.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalInterventional Neuroradiology
Volume18
Issue number2
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Polyglycolic Acid
Aneurysm
Prospective Studies
Safety
Angiography
poly(lactic acid)
Lost to Follow-Up
Pathologic Constriction
Demography
Technology

Keywords

  • Axium MicroFX
  • Coiling
  • Durability
  • PGLA
  • Raymond grade
  • Recanalization
  • Safety

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Axium MicroFX coil for the completing endovascular aneurysm surgery study (ACCESS) : A prospective evaluation of the safety and durability of axium MicroFX PGLA coils. / Waldau, Ben; Fargen, K. M.; Mack, W. J.; Wilson, N. M.; Khaldi, A.; Hoh, B. L.; Mocco, J.

In: Interventional Neuroradiology, Vol. 18, No. 2, 06.2012, p. 200-207.

Research output: Contribution to journalArticle

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