Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance

Igor Sorokin, Noah Canvasser, Vitaly Margulis, Yair Lotan, Ganesh Raj, Arthur Sagalowsky, Jeffrey C. Gahan, Jeffrey A. Cadeddu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose The overall recurrence rate of T1 renal cell carcinoma is low. We evaluated abdominal imaging after partial nephrectomy based on current guidelines for T1 renal cell carcinoma surveillance. Materials and Methods We retrospectively reviewed the records of patients with T1 renal cell carcinoma who underwent partial nephrectomy between 2006 and 2012 followed by abdominal imaging at our institution. Primary and secondary outcomes were the incidence and timing, respectively, of imaging diagnosed abdominal recurrences. A literature review was performed to summarize prior reports of recurrence incidence and timing after partial nephrectomy for T1 disease. Results A total of 160 patients with stage T1a and 37 with T1b underwent partial nephrectomy. Seven patients had an abdominal recurrence, including 3 with local and distant recurrences, and 4 with a metachronous contralateral kidney recurrence. The incidence of abdominal recurrence detected by imaging was higher in the T1b than in the T1a group (10.8% vs 1.9%, p = 0.024). Although it was not significant, median time to recurrence was earlier in T1b vs T1a cases (13 vs 37 months, p = 0.480). In each group recurrences developed after 3 years of suggested guideline surveillance. In the literature combined with the current study the time to median recurrence for T1b vs T1a was 24 vs 29 months (p = 0.226). Conclusions Recurrences detected by abdominal imaging developed earlier and more frequently in T1b than in T1a cases. Future recommendations for surveillance strategies after partial nephrectomy should distinguish T1a from T1b with less intense frequency of imaging for T1a. A longer period of surveillance should be considered since recurrences can develop beyond 3 years.

Original languageEnglish (US)
Pages (from-to)1021-1026
Number of pages6
JournalJournal of Urology
Volume198
Issue number5
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Nephrectomy
Renal Cell Carcinoma
Recurrence
Incidence
Guidelines
Kidney

Keywords

  • carcinoma
  • diagnostic imaging
  • kidney neoplasms
  • local
  • neoplasm recurrence
  • renal cell
  • watchful waiting

ASJC Scopus subject areas

  • Urology

Cite this

Sorokin, I., Canvasser, N., Margulis, V., Lotan, Y., Raj, G., Sagalowsky, A., ... Cadeddu, J. A. (2017). Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance. Journal of Urology, 198(5), 1021-1026. https://doi.org/10.1016/j.juro.2017.04.080

Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance. / Sorokin, Igor; Canvasser, Noah; Margulis, Vitaly; Lotan, Yair; Raj, Ganesh; Sagalowsky, Arthur; Gahan, Jeffrey C.; Cadeddu, Jeffrey A.

In: Journal of Urology, Vol. 198, No. 5, 01.11.2017, p. 1021-1026.

Research output: Contribution to journalArticle

Sorokin, I, Canvasser, N, Margulis, V, Lotan, Y, Raj, G, Sagalowsky, A, Gahan, JC & Cadeddu, JA 2017, 'Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance', Journal of Urology, vol. 198, no. 5, pp. 1021-1026. https://doi.org/10.1016/j.juro.2017.04.080
Sorokin, Igor ; Canvasser, Noah ; Margulis, Vitaly ; Lotan, Yair ; Raj, Ganesh ; Sagalowsky, Arthur ; Gahan, Jeffrey C. ; Cadeddu, Jeffrey A. / Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance. In: Journal of Urology. 2017 ; Vol. 198, No. 5. pp. 1021-1026.
@article{4efb9365a0d843b593e1dacf75bb060b,
title = "Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance",
abstract = "Purpose The overall recurrence rate of T1 renal cell carcinoma is low. We evaluated abdominal imaging after partial nephrectomy based on current guidelines for T1 renal cell carcinoma surveillance. Materials and Methods We retrospectively reviewed the records of patients with T1 renal cell carcinoma who underwent partial nephrectomy between 2006 and 2012 followed by abdominal imaging at our institution. Primary and secondary outcomes were the incidence and timing, respectively, of imaging diagnosed abdominal recurrences. A literature review was performed to summarize prior reports of recurrence incidence and timing after partial nephrectomy for T1 disease. Results A total of 160 patients with stage T1a and 37 with T1b underwent partial nephrectomy. Seven patients had an abdominal recurrence, including 3 with local and distant recurrences, and 4 with a metachronous contralateral kidney recurrence. The incidence of abdominal recurrence detected by imaging was higher in the T1b than in the T1a group (10.8{\%} vs 1.9{\%}, p = 0.024). Although it was not significant, median time to recurrence was earlier in T1b vs T1a cases (13 vs 37 months, p = 0.480). In each group recurrences developed after 3 years of suggested guideline surveillance. In the literature combined with the current study the time to median recurrence for T1b vs T1a was 24 vs 29 months (p = 0.226). Conclusions Recurrences detected by abdominal imaging developed earlier and more frequently in T1b than in T1a cases. Future recommendations for surveillance strategies after partial nephrectomy should distinguish T1a from T1b with less intense frequency of imaging for T1a. A longer period of surveillance should be considered since recurrences can develop beyond 3 years.",
keywords = "carcinoma, diagnostic imaging, kidney neoplasms, local, neoplasm recurrence, renal cell, watchful waiting",
author = "Igor Sorokin and Noah Canvasser and Vitaly Margulis and Yair Lotan and Ganesh Raj and Arthur Sagalowsky and Gahan, {Jeffrey C.} and Cadeddu, {Jeffrey A.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.juro.2017.04.080",
language = "English (US)",
volume = "198",
pages = "1021--1026",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Axial Abdominal Imaging after Partial Nephrectomy for T1 Renal Cell Carcinoma Surveillance

AU - Sorokin, Igor

AU - Canvasser, Noah

AU - Margulis, Vitaly

AU - Lotan, Yair

AU - Raj, Ganesh

AU - Sagalowsky, Arthur

AU - Gahan, Jeffrey C.

AU - Cadeddu, Jeffrey A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose The overall recurrence rate of T1 renal cell carcinoma is low. We evaluated abdominal imaging after partial nephrectomy based on current guidelines for T1 renal cell carcinoma surveillance. Materials and Methods We retrospectively reviewed the records of patients with T1 renal cell carcinoma who underwent partial nephrectomy between 2006 and 2012 followed by abdominal imaging at our institution. Primary and secondary outcomes were the incidence and timing, respectively, of imaging diagnosed abdominal recurrences. A literature review was performed to summarize prior reports of recurrence incidence and timing after partial nephrectomy for T1 disease. Results A total of 160 patients with stage T1a and 37 with T1b underwent partial nephrectomy. Seven patients had an abdominal recurrence, including 3 with local and distant recurrences, and 4 with a metachronous contralateral kidney recurrence. The incidence of abdominal recurrence detected by imaging was higher in the T1b than in the T1a group (10.8% vs 1.9%, p = 0.024). Although it was not significant, median time to recurrence was earlier in T1b vs T1a cases (13 vs 37 months, p = 0.480). In each group recurrences developed after 3 years of suggested guideline surveillance. In the literature combined with the current study the time to median recurrence for T1b vs T1a was 24 vs 29 months (p = 0.226). Conclusions Recurrences detected by abdominal imaging developed earlier and more frequently in T1b than in T1a cases. Future recommendations for surveillance strategies after partial nephrectomy should distinguish T1a from T1b with less intense frequency of imaging for T1a. A longer period of surveillance should be considered since recurrences can develop beyond 3 years.

AB - Purpose The overall recurrence rate of T1 renal cell carcinoma is low. We evaluated abdominal imaging after partial nephrectomy based on current guidelines for T1 renal cell carcinoma surveillance. Materials and Methods We retrospectively reviewed the records of patients with T1 renal cell carcinoma who underwent partial nephrectomy between 2006 and 2012 followed by abdominal imaging at our institution. Primary and secondary outcomes were the incidence and timing, respectively, of imaging diagnosed abdominal recurrences. A literature review was performed to summarize prior reports of recurrence incidence and timing after partial nephrectomy for T1 disease. Results A total of 160 patients with stage T1a and 37 with T1b underwent partial nephrectomy. Seven patients had an abdominal recurrence, including 3 with local and distant recurrences, and 4 with a metachronous contralateral kidney recurrence. The incidence of abdominal recurrence detected by imaging was higher in the T1b than in the T1a group (10.8% vs 1.9%, p = 0.024). Although it was not significant, median time to recurrence was earlier in T1b vs T1a cases (13 vs 37 months, p = 0.480). In each group recurrences developed after 3 years of suggested guideline surveillance. In the literature combined with the current study the time to median recurrence for T1b vs T1a was 24 vs 29 months (p = 0.226). Conclusions Recurrences detected by abdominal imaging developed earlier and more frequently in T1b than in T1a cases. Future recommendations for surveillance strategies after partial nephrectomy should distinguish T1a from T1b with less intense frequency of imaging for T1a. A longer period of surveillance should be considered since recurrences can develop beyond 3 years.

KW - carcinoma

KW - diagnostic imaging

KW - kidney neoplasms

KW - local

KW - neoplasm recurrence

KW - renal cell

KW - watchful waiting

UR - http://www.scopus.com/inward/record.url?scp=85029755925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029755925&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2017.04.080

DO - 10.1016/j.juro.2017.04.080

M3 - Article

C2 - 28442383

AN - SCOPUS:85029755925

VL - 198

SP - 1021

EP - 1026

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -