Avian pulmonary proteinosis

six cases and a review of the literature

Dayna A. Goldsmith, Asli Mete, Joseph B. Pesavento, John M Adaska

Research output: Contribution to journalArticle

Abstract

Pulmonary alveolar proteinosis (PAP) is a disease of surfactant clearance in which functional abnormalities in alveolar macrophages lead to accumulation of surfactant within alveoli in mammals. Histologic examination of 6 avian autopsies, including 4 chickens, a turkey, and a cockatiel, revealed accumulation of hypereosinophilic densely arrayed lamellar material in the lungs that was magenta by periodic acid–Schiff stain and diastase resistant. Transmission electron microscopy of the proteinaceous material in 2 cases demonstrated alternating electron-dense and electron-lucent lamellae that formed whorls and had a regular periodicity of 6–14 nm, consistent with pulmonary surfactant. Given the anatomic differences between avian and mammalian lungs, we designated the presented condition “pulmonary proteinosis,” which can be observed as both an incidental finding or, when severe, may be a contributing factor to death through respiratory failure.

Original languageEnglish (US)
JournalJournal of Veterinary Diagnostic Investigation
DOIs
StatePublished - Jan 1 2019

Fingerprint

lungs
Surface-Active Agents
Lung
surfactants
Cockatoos
Pulmonary Alveolar Proteinosis
Electrons
Pulmonary Surfactants
Incidental Findings
Alveolar Macrophages
Periodicity
Amylases
Transmission Electron Microscopy
Respiratory Insufficiency
electrons
Mammals
Autopsy
Chickens
Coloring Agents
periodicity

Keywords

  • Avian
  • poultry
  • pulmonary alveolar proteinosis
  • pulmonary proteinosis
  • surfactant

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Avian pulmonary proteinosis : six cases and a review of the literature. / Goldsmith, Dayna A.; Mete, Asli; Pesavento, Joseph B.; Adaska, John M.

In: Journal of Veterinary Diagnostic Investigation, 01.01.2019.

Research output: Contribution to journalArticle

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