Abstract
Pulmonary alveolar proteinosis (PAP) is a disease of surfactant clearance in which functional abnormalities in alveolar macrophages lead to accumulation of surfactant within alveoli in mammals. Histologic examination of 6 avian autopsies, including 4 chickens, a turkey, and a cockatiel, revealed accumulation of hypereosinophilic densely arrayed lamellar material in the lungs that was magenta by periodic acid–Schiff stain and diastase resistant. Transmission electron microscopy of the proteinaceous material in 2 cases demonstrated alternating electron-dense and electron-lucent lamellae that formed whorls and had a regular periodicity of 6–14 nm, consistent with pulmonary surfactant. Given the anatomic differences between avian and mammalian lungs, we designated the presented condition “pulmonary proteinosis,” which can be observed as both an incidental finding or, when severe, may be a contributing factor to death through respiratory failure.
| Original language | English (US) |
|---|---|
| Journal | Journal of Veterinary Diagnostic Investigation |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Avian
- poultry
- pulmonary alveolar proteinosis
- pulmonary proteinosis
- surfactant
ASJC Scopus subject areas
- veterinary(all)
Cite this
Avian pulmonary proteinosis : six cases and a review of the literature. / Goldsmith, Dayna A.; Mete, Asli; Pesavento, Joseph B.; Adaska, John M.
In: Journal of Veterinary Diagnostic Investigation, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Avian pulmonary proteinosis
T2 - six cases and a review of the literature
AU - Goldsmith, Dayna A.
AU - Mete, Asli
AU - Pesavento, Joseph B.
AU - Adaska, John M
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Pulmonary alveolar proteinosis (PAP) is a disease of surfactant clearance in which functional abnormalities in alveolar macrophages lead to accumulation of surfactant within alveoli in mammals. Histologic examination of 6 avian autopsies, including 4 chickens, a turkey, and a cockatiel, revealed accumulation of hypereosinophilic densely arrayed lamellar material in the lungs that was magenta by periodic acid–Schiff stain and diastase resistant. Transmission electron microscopy of the proteinaceous material in 2 cases demonstrated alternating electron-dense and electron-lucent lamellae that formed whorls and had a regular periodicity of 6–14 nm, consistent with pulmonary surfactant. Given the anatomic differences between avian and mammalian lungs, we designated the presented condition “pulmonary proteinosis,” which can be observed as both an incidental finding or, when severe, may be a contributing factor to death through respiratory failure.
AB - Pulmonary alveolar proteinosis (PAP) is a disease of surfactant clearance in which functional abnormalities in alveolar macrophages lead to accumulation of surfactant within alveoli in mammals. Histologic examination of 6 avian autopsies, including 4 chickens, a turkey, and a cockatiel, revealed accumulation of hypereosinophilic densely arrayed lamellar material in the lungs that was magenta by periodic acid–Schiff stain and diastase resistant. Transmission electron microscopy of the proteinaceous material in 2 cases demonstrated alternating electron-dense and electron-lucent lamellae that formed whorls and had a regular periodicity of 6–14 nm, consistent with pulmonary surfactant. Given the anatomic differences between avian and mammalian lungs, we designated the presented condition “pulmonary proteinosis,” which can be observed as both an incidental finding or, when severe, may be a contributing factor to death through respiratory failure.
KW - Avian
KW - poultry
KW - pulmonary alveolar proteinosis
KW - pulmonary proteinosis
KW - surfactant
UR - http://www.scopus.com/inward/record.url?scp=85061567920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061567920&partnerID=8YFLogxK
U2 - 10.1177/1040638719830753
DO - 10.1177/1040638719830753
M3 - Article
C2 - 30734659
AN - SCOPUS:85061567920
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
ER -