Avian Models with Spontaneous Autoimmune Diseases

Georg Wick, Leif Andersson, Karel Hala, M. Eric Gershwin, Carlo Selmi, Gisela F. Erf, Susan J. Lamont, Roswitha Sgonc

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Autoimmune diseases in human patients only become clinically manifest when the disease process has developed to a stage where functional compensation by the afflicted organ or system is not possible anymore. In order to understand the initial etiologic and pathogenic events that are generally not yet accessible in humans, appropriate animal models are required. In this respect, spontaneously developing models-albeit rare-reflect the situation in humans much more closely than experimentally induced models, including knockout and transgenic mice. The present chapter describes three spontaneous chicken models for human autoimmune diseases, the Obese strain (OS) with a Hashimoto-like autoimmune thyroiditis, the University of California at Davis lines 200 and 206 (UCD-200 and -206) with a scleroderma-like disease, and the amelanotic Smyth line with a vitiligo-like syndrome (SLV). Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome.

Original languageEnglish (US)
Pages (from-to)71-117
Number of pages47
JournalAdvances in Immunology
Volume92
DOIs
StatePublished - 2006

Fingerprint

Autoimmune Diseases
Chickens
Autoimmune Thyroiditis
Vitiligo
Inborn Genetic Diseases
Knockout Mice
Transgenic Mice
Animal Models
Genome

ASJC Scopus subject areas

  • Immunology

Cite this

Wick, G., Andersson, L., Hala, K., Gershwin, M. E., Selmi, C., Erf, G. F., ... Sgonc, R. (2006). Avian Models with Spontaneous Autoimmune Diseases. Advances in Immunology, 92, 71-117. https://doi.org/10.1016/S0065-2776(06)92002-1

Avian Models with Spontaneous Autoimmune Diseases. / Wick, Georg; Andersson, Leif; Hala, Karel; Gershwin, M. Eric; Selmi, Carlo; Erf, Gisela F.; Lamont, Susan J.; Sgonc, Roswitha.

In: Advances in Immunology, Vol. 92, 2006, p. 71-117.

Research output: Contribution to journalArticle

Wick, G, Andersson, L, Hala, K, Gershwin, ME, Selmi, C, Erf, GF, Lamont, SJ & Sgonc, R 2006, 'Avian Models with Spontaneous Autoimmune Diseases', Advances in Immunology, vol. 92, pp. 71-117. https://doi.org/10.1016/S0065-2776(06)92002-1
Wick, Georg ; Andersson, Leif ; Hala, Karel ; Gershwin, M. Eric ; Selmi, Carlo ; Erf, Gisela F. ; Lamont, Susan J. ; Sgonc, Roswitha. / Avian Models with Spontaneous Autoimmune Diseases. In: Advances in Immunology. 2006 ; Vol. 92. pp. 71-117.
@article{cd2b298c25c74e4eb73e64d67dbb57cc,
title = "Avian Models with Spontaneous Autoimmune Diseases",
abstract = "Autoimmune diseases in human patients only become clinically manifest when the disease process has developed to a stage where functional compensation by the afflicted organ or system is not possible anymore. In order to understand the initial etiologic and pathogenic events that are generally not yet accessible in humans, appropriate animal models are required. In this respect, spontaneously developing models-albeit rare-reflect the situation in humans much more closely than experimentally induced models, including knockout and transgenic mice. The present chapter describes three spontaneous chicken models for human autoimmune diseases, the Obese strain (OS) with a Hashimoto-like autoimmune thyroiditis, the University of California at Davis lines 200 and 206 (UCD-200 and -206) with a scleroderma-like disease, and the amelanotic Smyth line with a vitiligo-like syndrome (SLV). Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome.",
author = "Georg Wick and Leif Andersson and Karel Hala and Gershwin, {M. Eric} and Carlo Selmi and Erf, {Gisela F.} and Lamont, {Susan J.} and Roswitha Sgonc",
year = "2006",
doi = "10.1016/S0065-2776(06)92002-1",
language = "English (US)",
volume = "92",
pages = "71--117",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Avian Models with Spontaneous Autoimmune Diseases

AU - Wick, Georg

AU - Andersson, Leif

AU - Hala, Karel

AU - Gershwin, M. Eric

AU - Selmi, Carlo

AU - Erf, Gisela F.

AU - Lamont, Susan J.

AU - Sgonc, Roswitha

PY - 2006

Y1 - 2006

N2 - Autoimmune diseases in human patients only become clinically manifest when the disease process has developed to a stage where functional compensation by the afflicted organ or system is not possible anymore. In order to understand the initial etiologic and pathogenic events that are generally not yet accessible in humans, appropriate animal models are required. In this respect, spontaneously developing models-albeit rare-reflect the situation in humans much more closely than experimentally induced models, including knockout and transgenic mice. The present chapter describes three spontaneous chicken models for human autoimmune diseases, the Obese strain (OS) with a Hashimoto-like autoimmune thyroiditis, the University of California at Davis lines 200 and 206 (UCD-200 and -206) with a scleroderma-like disease, and the amelanotic Smyth line with a vitiligo-like syndrome (SLV). Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome.

AB - Autoimmune diseases in human patients only become clinically manifest when the disease process has developed to a stage where functional compensation by the afflicted organ or system is not possible anymore. In order to understand the initial etiologic and pathogenic events that are generally not yet accessible in humans, appropriate animal models are required. In this respect, spontaneously developing models-albeit rare-reflect the situation in humans much more closely than experimentally induced models, including knockout and transgenic mice. The present chapter describes three spontaneous chicken models for human autoimmune diseases, the Obese strain (OS) with a Hashimoto-like autoimmune thyroiditis, the University of California at Davis lines 200 and 206 (UCD-200 and -206) with a scleroderma-like disease, and the amelanotic Smyth line with a vitiligo-like syndrome (SLV). Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome.

UR - http://www.scopus.com/inward/record.url?scp=33751501713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751501713&partnerID=8YFLogxK

U2 - 10.1016/S0065-2776(06)92002-1

DO - 10.1016/S0065-2776(06)92002-1

M3 - Article

C2 - 17145302

AN - SCOPUS:33751501713

VL - 92

SP - 71

EP - 117

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

ER -