Autoradiographic maps of regional brain glucose consumption in resting, awake rats using [14C] 2-deoxyglucose

W. J. Schwartz, Frank R Sharp

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

The 2-deoxy-D-[14C]glucose (2-DG) autoradiographic method for determining regional brain glucose consumption has been applied successfully by a number of workers for mapping the alterations of brain glucose consumption which occur in association with experimental alterations of brain functional activity. This paper provides a framework for the interpretation of these and further studies by presenting: (1) the pattern of regional brain glucose consumption in the normal, resting, awake rat; (2) the anatomical identities of brain structures which on autoradiographs appear only as regional variations of optical density. For this purpose, a series of 2-DG autoradiographs of coronal brain sections from an injected animal is compared with adjacent labeled Nissl sections.

Original languageEnglish (US)
Pages (from-to)335-359
Number of pages25
JournalJournal of Comparative Neurology
Volume177
Issue number2
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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