Autoradiographic Localization of Vitamin A in the Kidney of Rats

Charles Plopper; D. L. Wallace; T. J. Bucci; H. E. Sauberlich

doi:10.3181/00379727-155-39758

Autoradiographic Localization of Vitamin A in the Kidney of Rats

Charles Plopper, D. L. Wallace, T. J. Bucci, H. E. Sauberlich

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The distribution of vitamin A in the kidney was investigated autoradi-ographically. Three hours after intravenous administration of [11, 12-³H]retinyl acetate to vitamin A-deficient rats, the vast majority of the label was present in cells of the proximal convoluted tubules. A very small number of endothelial cells in the medulla and interstitial cells in the cortex were also labeled. The evidence strongly suggests that the proximal convoluted tubule is the major renal site for vitamin A localization. The precise role the kidney plays in overall vitamin A metabolism remains uncertain.

Original language	English (US)
Pages (from-to)	124-127
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	155
Issue number	1
DOIs	https://doi.org/10.3181/00379727-155-39758
State	Published - Jan 1 1977
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "The distribution of vitamin A in the kidney was investigated autoradi-ographically. Three hours after intravenous administration of [11, 12-3H]retinyl acetate to vitamin A-deficient rats, the vast majority of the label was present in cells of the proximal convoluted tubules. A very small number of endothelial cells in the medulla and interstitial cells in the cortex were also labeled. The evidence strongly suggests that the proximal convoluted tubule is the major renal site for vitamin A localization. The precise role the kidney plays in overall vitamin A metabolism remains uncertain.",

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AU - Wallace, D. L.

AU - Bucci, T. J.

AU - Sauberlich, H. E.

PY - 1977/1/1

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N2 - The distribution of vitamin A in the kidney was investigated autoradi-ographically. Three hours after intravenous administration of [11, 12-3H]retinyl acetate to vitamin A-deficient rats, the vast majority of the label was present in cells of the proximal convoluted tubules. A very small number of endothelial cells in the medulla and interstitial cells in the cortex were also labeled. The evidence strongly suggests that the proximal convoluted tubule is the major renal site for vitamin A localization. The precise role the kidney plays in overall vitamin A metabolism remains uncertain.

AB - The distribution of vitamin A in the kidney was investigated autoradi-ographically. Three hours after intravenous administration of [11, 12-3H]retinyl acetate to vitamin A-deficient rats, the vast majority of the label was present in cells of the proximal convoluted tubules. A very small number of endothelial cells in the medulla and interstitial cells in the cortex were also labeled. The evidence strongly suggests that the proximal convoluted tubule is the major renal site for vitamin A localization. The precise role the kidney plays in overall vitamin A metabolism remains uncertain.

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