The distribution of vitamin A in the kidney was investigated autoradi-ographically. Three hours after intravenous administration of [11, 12-3H]retinyl acetate to vitamin A-deficient rats, the vast majority of the label was present in cells of the proximal convoluted tubules. A very small number of endothelial cells in the medulla and interstitial cells in the cortex were also labeled. The evidence strongly suggests that the proximal convoluted tubule is the major renal site for vitamin A localization. The precise role the kidney plays in overall vitamin A metabolism remains uncertain.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jan 1 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)