Autoradiographic localization of vitamin A in the adrenal gland of rats

D. L. Wallace, Charles Plopper, T. J. Bucci, H. E. Sauberlich

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Abstract

Cellular distribution of vitamin A in the rat adrenal was evaluated by autoradiography. Vitamin A was concentrated in the lipid droplets of epithelial cells of the zona fasciculata and zona reticularis. A small amount of vitamin A was also present in the cytoplasm and nucleus of these cells. The zona glomerulosa contained very little vitamin A either in lipid droplets or in the remainder of the cell. The medulla had essentially no vitamin A. Such strong cellular specificity for uptake of vitamin A by the cells of the zona fasciculata and zona reticularis supports the hypothesis that vitamin A is involved in synthesis of glucocorticoid hormones.

Original languageEnglish (US)
Pages (from-to)1693-1697
Number of pages5
JournalLife Sciences
Volume17
Issue number11
DOIs
StatePublished - Dec 1 1975
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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