Autophagy and urothelial carcinoma of the bladder: A review

Thenappan Chandrasekar, Christopher P Evans

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the past few decades. The mortality is mainly driven by muscle invasive bladder cancer, but the cancer burden remains high even in nonmuscle invasive bladder cancer due to high recurrence rates and risk of progression. While apoptosis deregulation has long been an established pathway for cancer progression, nonapoptotic pathways have gained prominence of late. Recent research in the role of autophagy in other malignancies, including its role in treatment resistance, has led to greater interest in the role of autophagy in bladder cancer. Herein, we summarize the literature regarding the role of autophagy in bladder cancer progression and treatment resistance. We address it by systematically reviewing treatment modalities for nonmuscle invasive and muscle invasive bladder cancer.

Original languageEnglish (US)
Pages (from-to)S89-S97
JournalInvestigative and Clinical Urology
Volume57
DOIs
StatePublished - 2016

Fingerprint

Autophagy
Urinary Bladder Neoplasms
Urinary Bladder
Carcinoma
Mortality
Neoplasms
Muscles
Apoptosis
Morbidity
Recurrence
Incidence
Research

Keywords

  • Autophagy
  • Drug resistance
  • Urinary bladder neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Autophagy and urothelial carcinoma of the bladder : A review. / Chandrasekar, Thenappan; Evans, Christopher P.

In: Investigative and Clinical Urology, Vol. 57, 2016, p. S89-S97.

Research output: Contribution to journalReview article

@article{9e656ddf3c1e4fc48956bbf3d1d3ff8f,
title = "Autophagy and urothelial carcinoma of the bladder: A review",
abstract = "The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the past few decades. The mortality is mainly driven by muscle invasive bladder cancer, but the cancer burden remains high even in nonmuscle invasive bladder cancer due to high recurrence rates and risk of progression. While apoptosis deregulation has long been an established pathway for cancer progression, nonapoptotic pathways have gained prominence of late. Recent research in the role of autophagy in other malignancies, including its role in treatment resistance, has led to greater interest in the role of autophagy in bladder cancer. Herein, we summarize the literature regarding the role of autophagy in bladder cancer progression and treatment resistance. We address it by systematically reviewing treatment modalities for nonmuscle invasive and muscle invasive bladder cancer.",
keywords = "Autophagy, Drug resistance, Urinary bladder neoplasms",
author = "Thenappan Chandrasekar and Evans, {Christopher P}",
year = "2016",
doi = "10.4111/icu.2016.57.S1.S89",
language = "English (US)",
volume = "57",
pages = "S89--S97",
journal = "Investigative and Clinical Urology",
issn = "2466-0493",
publisher = "Korean Urological Association",

}

TY - JOUR

T1 - Autophagy and urothelial carcinoma of the bladder

T2 - A review

AU - Chandrasekar, Thenappan

AU - Evans, Christopher P

PY - 2016

Y1 - 2016

N2 - The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the past few decades. The mortality is mainly driven by muscle invasive bladder cancer, but the cancer burden remains high even in nonmuscle invasive bladder cancer due to high recurrence rates and risk of progression. While apoptosis deregulation has long been an established pathway for cancer progression, nonapoptotic pathways have gained prominence of late. Recent research in the role of autophagy in other malignancies, including its role in treatment resistance, has led to greater interest in the role of autophagy in bladder cancer. Herein, we summarize the literature regarding the role of autophagy in bladder cancer progression and treatment resistance. We address it by systematically reviewing treatment modalities for nonmuscle invasive and muscle invasive bladder cancer.

AB - The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the past few decades. The mortality is mainly driven by muscle invasive bladder cancer, but the cancer burden remains high even in nonmuscle invasive bladder cancer due to high recurrence rates and risk of progression. While apoptosis deregulation has long been an established pathway for cancer progression, nonapoptotic pathways have gained prominence of late. Recent research in the role of autophagy in other malignancies, including its role in treatment resistance, has led to greater interest in the role of autophagy in bladder cancer. Herein, we summarize the literature regarding the role of autophagy in bladder cancer progression and treatment resistance. We address it by systematically reviewing treatment modalities for nonmuscle invasive and muscle invasive bladder cancer.

KW - Autophagy

KW - Drug resistance

KW - Urinary bladder neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84974716010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974716010&partnerID=8YFLogxK

U2 - 10.4111/icu.2016.57.S1.S89

DO - 10.4111/icu.2016.57.S1.S89

M3 - Review article

C2 - 27326411

AN - SCOPUS:84974716010

VL - 57

SP - S89-S97

JO - Investigative and Clinical Urology

JF - Investigative and Clinical Urology

SN - 2466-0493

ER -