Abstract
High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.
Original language | English (US) |
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Title of host publication | Ophthalmic Technologies XXV |
Editors | Arthur Ho, Fabrice Manns, Per G. Soderberg |
Publisher | SPIE |
Volume | 9307 |
ISBN (Electronic) | 9781628413977 |
DOIs | |
State | Published - Jan 1 2015 |
Event | 25th Conference on Ophthalmic Technologies - San Francisco, United States Duration: Feb 7 2015 → Feb 8 2015 |
Other
Other | 25th Conference on Ophthalmic Technologies |
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Country/Territory | United States |
City | San Francisco |
Period | 2/7/15 → 2/8/15 |
Keywords
- en face OCT
- focus stacking
- GPU acceleration
- high-resolution OCT
- variable focus lens
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging