Abstract
High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.
| Original language | English (US) |
|---|---|
| Title of host publication | Ophthalmic Technologies XXV |
| Editors | Arthur Ho, Fabrice Manns, Per G. Soderberg |
| Publisher | SPIE |
| Volume | 9307 |
| ISBN (Electronic) | 9781628413977 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Event | 25th Conference on Ophthalmic Technologies - San Francisco, United States Duration: Feb 7 2015 → Feb 8 2015 |
Other
| Other | 25th Conference on Ophthalmic Technologies |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/7/15 → 2/8/15 |
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Keywords
- en face OCT
- focus stacking
- GPU acceleration
- high-resolution OCT
- variable focus lens
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. / Cua, Michelle; Liu, Xiyun; Miao, Dongkai; Lee, Sujin; Lee, Sieun; Bonora, Stefano; Zawadzki, Robert; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.
Ophthalmic Technologies XXV. ed. / Arthur Ho; Fabrice Manns; Per G. Soderberg. Vol. 9307 SPIE, 2015. 93071D.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm
AU - Cua, Michelle
AU - Liu, Xiyun
AU - Miao, Dongkai
AU - Lee, Sujin
AU - Lee, Sieun
AU - Bonora, Stefano
AU - Zawadzki, Robert
AU - Mackenzie, Paul J.
AU - Jian, Yifan
AU - Sarunic, Marinko V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.
AB - High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.
KW - en face OCT
KW - focus stacking
KW - GPU acceleration
KW - high-resolution OCT
KW - variable focus lens
UR - http://www.scopus.com/inward/record.url?scp=84928542397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928542397&partnerID=8YFLogxK
U2 - 10.1117/12.2079665
DO - 10.1117/12.2079665
M3 - Conference contribution
AN - SCOPUS:84928542397
VL - 9307
BT - Ophthalmic Technologies XXV
A2 - Ho, Arthur
A2 - Manns, Fabrice
A2 - Soderberg, Per G.
PB - SPIE
ER -