Automated three-chambered social approach task for mice.

M. Yang, Jill L. Silverman, Jacqueline N. Crawley

Research output: Contribution to journalArticle

Abstract

Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions, impaired communication, and repetitive behaviors with restricted interests. Direct social approach in mice has strong face validity to simple social approach behaviors in humans, which are frequently impaired in autism. This unit presents a basic protocol for a standardized, high-throughput social approach test for assaying mouse sociability. Our automated three-chambered social approach task quantifies direct social approach behaviors when a subject mouse is presented with the choice of spending time with either a novel mouse or a novel object. Sociability is defined as the subject mouse spending more time in the chamber containing the novel target mouse than in the chamber containing the inanimate novel object. The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection.

Original languageEnglish (US)
JournalCurrent protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
VolumeChapter 8
StatePublished - Jul 2011
Externally publishedYes

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Choice Behavior
Autistic Disorder
Interpersonal Relations
Reproducibility of Results
Communication

ASJC Scopus subject areas

  • Medicine(all)

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Automated three-chambered social approach task for mice. / Yang, M.; Silverman, Jill L.; Crawley, Jacqueline N.

In: Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.], Vol. Chapter 8, 07.2011.

Research output: Contribution to journalArticle

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