@inproceedings{4420ca2455214695bf6179bae57b2691,
title = "Automated Assessment of the Curliness of Collagen Fiber in Breast Cancer",
abstract = "The growth and spread of breast cancer are influenced by the composition and structural properties of collagen in the extracellular matrix of tumors. Straight alignment of collagen has been attributed to tumor cell migration, which is correlated with tumor progression and metastasis in breast cancer. Thus, there is a need to characterize collagen alignment to study its value as a prognostic biomarker. We present a framework to characterize the curliness of collagen fibers in breast cancer images from DUET (DUal-mode Emission and Transmission) studies on hematoxylin and eosin (H&E) stained tissue samples. Our novel approach highlights the characteristic fiber gradients using a standard ridge detection method before feeding into the convolutional neural network. Experiments were performed on patches of breast cancer images containing straight or curly collagen. The proposed approach outperforms in terms of area under the curve against transfer learning methods trained directly on the original patches. We also explore a feature fusion strategy to combine feature representations of both the original patches and their ridge filter responses.",
keywords = "Collagen fiber, Deep learning, Digital pathology, Ridge detection",
author = "David Paredes and Prateek Prasanna and Christina Preece and Rajarsi Gupta and Farzad Fereidouni and Dimitris Samaras and Tahsin Kurc and Levenson, {Richard M.} and Patricia Thompson-Carino and Joel Saltz and Chao Chen",
note = "Funding Information: This work was supported in part by National Cancer Institute grants 3U24CA215109, 1UG3CA225021, 1U24CA180924 and its supplement 3U24CA180924-05S2, as well as the grant R33CA202881 and its supplement 3R33CA202881-02S1. Partial support for this effort was also funded through the generosity of Bob Beals and Betsy Barton. Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.; Workshops held at the 16th European Conference on Computer Vision, ECCV 2020 ; Conference date: 23-08-2020 Through 28-08-2020",
year = "2020",
doi = "10.1007/978-3-030-66415-2_17",
language = "English (US)",
isbn = "9783030664145",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "267--279",
editor = "Adrien Bartoli and Andrea Fusiello",
booktitle = "Computer Vision – ECCV 2020 Workshops, Proceedings",
address = "Germany",
}