Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology

Roni M. Shtein, Joanne F. Shen, Anthony N. Kuo, Kristin M. Hammersmith, Jennifer Y. Li, Mitchell P. Weikert

Research output: Contribution to journalArticle

Abstract

Purpose: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. Methods: Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citations, which were reviewed in abstract form. Of these, 48 were selected for a full-text review, and 13 met the inclusion criteria and were assigned a quality-of-evidence rating by the panel methodologist. Eight of these studies were rated level II and 5 were rated level III; there were no level I studies. Results: This analysis included 10 studies of the use of autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial defect. Several studies showed good effectiveness, with some improvement in symptoms, signs, or both. Eight of the studies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1 clinical sign. For persistent epithelial defects, all of the studies showed improvement, with 3 of the 4 demonstrating an improvement rate of more than 90%. Adverse events were rare. Conclusions: Although autologous serum-based tears may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions are limited owing to the absence of controlled trials.

Original languageEnglish (US)
JournalOphthalmology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Eye Diseases
Ophthalmic Solutions
Serum
Tears
PubMed
Libraries
Signs and Symptoms
Databases
Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease : A Report by the American Academy of Ophthalmology. / Shtein, Roni M.; Shen, Joanne F.; Kuo, Anthony N.; Hammersmith, Kristin M.; Li, Jennifer Y.; Weikert, Mitchell P.

In: Ophthalmology, 01.01.2019.

Research output: Contribution to journalArticle

Shtein, Roni M. ; Shen, Joanne F. ; Kuo, Anthony N. ; Hammersmith, Kristin M. ; Li, Jennifer Y. ; Weikert, Mitchell P. / Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease : A Report by the American Academy of Ophthalmology. In: Ophthalmology. 2019.
@article{efa64adcb2e244e5b2ea908ddee97312,
title = "Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology",
abstract = "Purpose: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. Methods: Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citations, which were reviewed in abstract form. Of these, 48 were selected for a full-text review, and 13 met the inclusion criteria and were assigned a quality-of-evidence rating by the panel methodologist. Eight of these studies were rated level II and 5 were rated level III; there were no level I studies. Results: This analysis included 10 studies of the use of autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial defect. Several studies showed good effectiveness, with some improvement in symptoms, signs, or both. Eight of the studies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1 clinical sign. For persistent epithelial defects, all of the studies showed improvement, with 3 of the 4 demonstrating an improvement rate of more than 90{\%}. Adverse events were rare. Conclusions: Although autologous serum-based tears may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions are limited owing to the absence of controlled trials.",
author = "Shtein, {Roni M.} and Shen, {Joanne F.} and Kuo, {Anthony N.} and Hammersmith, {Kristin M.} and Li, {Jennifer Y.} and Weikert, {Mitchell P.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.ophtha.2019.08.018",
language = "English (US)",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease

T2 - A Report by the American Academy of Ophthalmology

AU - Shtein, Roni M.

AU - Shen, Joanne F.

AU - Kuo, Anthony N.

AU - Hammersmith, Kristin M.

AU - Li, Jennifer Y.

AU - Weikert, Mitchell P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. Methods: Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citations, which were reviewed in abstract form. Of these, 48 were selected for a full-text review, and 13 met the inclusion criteria and were assigned a quality-of-evidence rating by the panel methodologist. Eight of these studies were rated level II and 5 were rated level III; there were no level I studies. Results: This analysis included 10 studies of the use of autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial defect. Several studies showed good effectiveness, with some improvement in symptoms, signs, or both. Eight of the studies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1 clinical sign. For persistent epithelial defects, all of the studies showed improvement, with 3 of the 4 demonstrating an improvement rate of more than 90%. Adverse events were rare. Conclusions: Although autologous serum-based tears may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions are limited owing to the absence of controlled trials.

AB - Purpose: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. Methods: Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citations, which were reviewed in abstract form. Of these, 48 were selected for a full-text review, and 13 met the inclusion criteria and were assigned a quality-of-evidence rating by the panel methodologist. Eight of these studies were rated level II and 5 were rated level III; there were no level I studies. Results: This analysis included 10 studies of the use of autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial defect. Several studies showed good effectiveness, with some improvement in symptoms, signs, or both. Eight of the studies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1 clinical sign. For persistent epithelial defects, all of the studies showed improvement, with 3 of the 4 demonstrating an improvement rate of more than 90%. Adverse events were rare. Conclusions: Although autologous serum-based tears may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions are limited owing to the absence of controlled trials.

UR - http://www.scopus.com/inward/record.url?scp=85072562126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072562126&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2019.08.018

DO - 10.1016/j.ophtha.2019.08.018

M3 - Article

AN - SCOPUS:85072562126

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

ER -