Autologous bone marrow-derived cell therapies for retinal disease

Elad Moisseiev, Susanna Soon Chun Park

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autologous bone marrow-derived cell therapy is being explored in clinical trial as potential treatment for ischemic or degenerative retinal conditions. The rationale for exploring this therapy is that there is preclinical evidence showing that certain stem cells in bone marrow can have a regenerative effect on ischemic or degenerating retina. Direct tissue incorporation and paracrine trophic effects of bone marrow stem cells have been demonstrated in animal models. The cells in bone marrow that have been studied include mesenchymal stem cells, mononuclear cells, and CD34+ cells. These cells can be harvested easily from bone marrow. With autologous cell therapy, no systemic immunosuppression or donor matching is needed. Early reports of phase 1 clinical trials using intravitreal autologous bone marrow CD34+ or mononuclear cells show no safety or feasibility issues associated with the cell therapy. Larger studies are needed to determine the full safety profile and therapeutic potential of these cells.

Original languageEnglish (US)
Title of host publicationCellular Therapies for Retinal Disease
Subtitle of host publicationA Strategic Approach
PublisherSpringer International Publishing
Pages79-94
Number of pages16
ISBN (Electronic)9783319494791
ISBN (Print)9783319494777
DOIs
StatePublished - Jun 20 2017

Keywords

  • Autologous cell therapy
  • Bone marrow cell
  • CD34+ cell
  • Endothelial progenitor cell
  • Hematopoietic stem cell
  • Mesenchymal stem cell
  • Retina
  • Retinal degeneration
  • Retinal ischemia
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Moisseiev, E., & Park, S. S. C. (2017). Autologous bone marrow-derived cell therapies for retinal disease. In Cellular Therapies for Retinal Disease: A Strategic Approach (pp. 79-94). Springer International Publishing. https://doi.org/10.1007/978-3-319-49479-1_7