Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus

Naomi Balaban, Tzipora Goldkorn, Rachael T. Nhan, Luong B. Dang, Steven Scott, Rose M. Ridgley, Avraham Rasooly, Susan C. Wright, James W. Larrick, Reuven Rasooly, James R. Carlson

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

Staphylococcus aureus causes pathologies ranging from minor skin infections to life-threatening diseases. Pathogenic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule, RNAIII. The S. aureus protein called RAP (RNAIII activating protein) activates RNAIII, and a peptide called RIP (RNAIII inhibiting peptide), produced by a nonpathogenic bacteria, inhibits RNAIII. Mice vaccinated with RAP or treated with purified or synthetic RIP were protected from S. aureus pathology. Thus, these two molecules may provide useful approaches for the prevention and treatment of diseases caused by S. aureus.

Original languageEnglish (US)
Pages (from-to)438-440
Number of pages3
JournalScience
Volume280
Issue number5362
DOIs
StatePublished - Apr 17 1998

ASJC Scopus subject areas

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    Balaban, N., Goldkorn, T., Nhan, R. T., Dang, L. B., Scott, S., Ridgley, R. M., Rasooly, A., Wright, S. C., Larrick, J. W., Rasooly, R., & Carlson, J. R. (1998). Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science, 280(5362), 438-440. https://doi.org/10.1126/science.280.5362.438