Autoimmunity, Autoantibodies, and Autism Spectrum Disorder

Elizabeth Edmiston, Paul Ashwood, Judith A Van de Water

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is the fastest growing neurodevelopmental disability worldwide. Alarmingly, for the majority of cases, the causes of ASD are largely unknown, but it is becoming increasingly accepted that ASD is no longer defined simply as a behavioral disorder, but rather as a highly complex and heterogeneous biological disorder. Although research has focused on the identification of genetic abnormalities, emerging studies increasingly suggest that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in ASD. This review summarizes the investigations implicating autoimmunity and autoantibodies in ASD.

Original languageEnglish (US)
JournalBiological Psychiatry
DOIs
StateAccepted/In press - Jun 1 2016

Keywords

  • Autism
  • Autoimmunity
  • Immune
  • Maternal autoantibodies
  • Neurodevelopmental
  • Pregnancy

ASJC Scopus subject areas

  • Biological Psychiatry

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