Autoimmune T cells lured to a FASL web of death by MSCs

William J Murphy; Jan Nolta

doi:10.1016/j.stem.2012.04.013

Autoimmune T cells lured to a FASL web of death by MSCs

William J Murphy, Jan Nolta

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

Original language	English (US)
Pages (from-to)	485-487
Number of pages	3
Journal	Cell Stem Cell
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2012.04.013
State	Published - May 4 2012

ASJC Scopus subject areas

Cell Biology
Molecular Medicine
Genetics

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title = "Autoimmune T cells lured to a FASL web of death by MSCs",

abstract = "Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.",

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AB - Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

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Autoimmune T cells lured to a FASL web of death by MSCs

Abstract

ASJC Scopus subject areas

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