Autoimmune T cells lured to a FASL web of death by MSCs

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Abstract

Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
JournalCell Stem Cell
Volume10
Issue number5
DOIs
StatePublished - May 4 2012

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ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

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