Recently, an immunodeficiency analogous to acquired selective agammaglobulinemia of humans has been described in a line of University of California, Davis, chickens (UCD 140). This syndrome is characterized by normal immunoglobulin synthesis early in life followed by a variable expression dysgammaglobulinemia. Serial observation of these birds, and age matched controls, reveals, in addition to their abnormal levels of immunoglobulins, accelerated morbidity and mortality associated with the frequent development of Coombs' positive hemolytic anemia, serum anti-γ-globulin activity, and cryoprecipitates; though these traits are highly heritable, the exact mode of inheritance is as yet obscure. Nonetheless, there are statistically significant correlations between several of these features suggesting a common etiology. Dysgammaglobulinemic birds possess cryoprecipitate more frequently than unaffected birds, and autoimmune hemolytic anemia is frequently associated with the immunodeficiency. Additionally, males are more often Coombs' positive and more frequently exhibit serum cryoprecipitate than females. The mechanisms for the defects are unclear, but an abnormality in a regulatory cell population is suggested.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine