Abstract
Liver transplantation (LT) is a standard therapeutic approach for the treatment of end-stage acute and chronic liver disease of various etiologies including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). Results of LT for these autoimmune liver diseases are good, with a patient survival of 80 to 85% at 5 yr after LT. Transplant recipients, however, experience various complications, such as acute and chronic rejection, recurrence of disease, and chronic hepatitis. Recurrence of disease on the graft may be influenced by the genetic background of the recipient as well as other factors such as the degree of immunosuppression. Interestingly, autoimmunity and autoimmune disease can occur de novo following LT even for non-autoimmune liver diseases. However, the mechanisms that lead to autoimmunity or recurrence of autoimmune liver diseases after LT have not yet been defined. This chapter focuses on recurrence and occurrence of autoimmune diseases in transplanted livers.
| Original language | English (US) |
|---|---|
| Title of host publication | Liver Immunology: Principles and Practice |
| Publisher | Humana Press |
| Pages | 451-457 |
| Number of pages | 7 |
| ISBN (Print) | 9781588298188 |
| DOIs | |
| State | Published - 2007 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Autoimmune diseases in transplanted livers. / Ishibashi, Hiromi; Shimoda, Shinji; Nakamura, Minoru; Gershwin, M. Eric.
Liver Immunology: Principles and Practice. Humana Press, 2007. p. 451-457.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Autoimmune diseases in transplanted livers
AU - Ishibashi, Hiromi
AU - Shimoda, Shinji
AU - Nakamura, Minoru
AU - Gershwin, M. Eric
PY - 2007
Y1 - 2007
N2 - Liver transplantation (LT) is a standard therapeutic approach for the treatment of end-stage acute and chronic liver disease of various etiologies including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). Results of LT for these autoimmune liver diseases are good, with a patient survival of 80 to 85% at 5 yr after LT. Transplant recipients, however, experience various complications, such as acute and chronic rejection, recurrence of disease, and chronic hepatitis. Recurrence of disease on the graft may be influenced by the genetic background of the recipient as well as other factors such as the degree of immunosuppression. Interestingly, autoimmunity and autoimmune disease can occur de novo following LT even for non-autoimmune liver diseases. However, the mechanisms that lead to autoimmunity or recurrence of autoimmune liver diseases after LT have not yet been defined. This chapter focuses on recurrence and occurrence of autoimmune diseases in transplanted livers.
AB - Liver transplantation (LT) is a standard therapeutic approach for the treatment of end-stage acute and chronic liver disease of various etiologies including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). Results of LT for these autoimmune liver diseases are good, with a patient survival of 80 to 85% at 5 yr after LT. Transplant recipients, however, experience various complications, such as acute and chronic rejection, recurrence of disease, and chronic hepatitis. Recurrence of disease on the graft may be influenced by the genetic background of the recipient as well as other factors such as the degree of immunosuppression. Interestingly, autoimmunity and autoimmune disease can occur de novo following LT even for non-autoimmune liver diseases. However, the mechanisms that lead to autoimmunity or recurrence of autoimmune liver diseases after LT have not yet been defined. This chapter focuses on recurrence and occurrence of autoimmune diseases in transplanted livers.
UR - http://www.scopus.com/inward/record.url?scp=84889953926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889953926&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-518-3_35
DO - 10.1007/978-1-59745-518-3_35
M3 - Chapter
SN - 9781588298188
SP - 451
EP - 457
BT - Liver Immunology: Principles and Practice
PB - Humana Press
ER -