AutoCyte Prep® system vs. conventional cervical cytology: Comparison based on 2,156 cases

Lisa Minge, Maureen Fleming, Thomas VanGeem, John W Bishop

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

OBJECTIVE: To compare the AutoCyte Prep® system (Burlington, North Carolina) with conventional cervical cytology in a university medical center laboratory. STUDY DESIGN: Split-sample conventional and AutoCyte Preps® were examined for 2,156 cases. Same-patient conventional and Prep® slides were submitted to separate cytotechnologists blindly. The results were compared on review by a cytopathologist. The Prep® slides were subsequently scanned on the AutoCyte Screen® automated interactive system, with manual review of the flagged cases. The results were compared with anatomic pathology follow-up when available. RESULTS: Of the 158 squamous intraepithelial lesions (SILs) found by both methods, 78% were found by AutoCyte Prep®, while 59% were found by conventional smear (P <.01). Among the discordant cases, thin-layer slides revealed 88% more LSIL lesions (P< .05), a comparable number of high grade SIL lesions and a single case of adenocarcinoma that was ambiguous on the conventional slide. The addition of AutoCyte® assisted primary screening demonstrated a net benefit, recovering additional cases referenced as atypical glandular cells of undetermined significance and as high grade SIL. CONCLUSION: The AutoCyte Prep® system affords excellent cellular presentations and superior sensitivity for SILs when compared to the conventional technique. The use of AutoCyte Screen® for primary screening demonstrated performance equivalent to manual screening, with a significant improvement in sensitivity when measured against biopsy results.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume45
Issue number3
StatePublished - Mar 2000

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Keywords

  • AutoCyte®
  • Cervical smears
  • Cervix neoplasms
  • Computer-assisted diagnosis
  • Mass screening

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

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