Autoantibodies to cerebellum in children with autism associate with behavior

Paula Goines, Lori Haapanen, Robert Boyce, Paul Duncanson, Daniel Braunschweig, Lora Delwiche, Robin L Hansen, Irva Hertz-Picciotto, Paul Ashwood, Judith A Van de Water

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Autism is a heterogeneous disorder with a poorly understood biological basis. Some children with autism harbor plasma autoantibodies that target brain proteins. Similarly, some mothers of children with autism produce antibodies specific to autism that target pairs of fetal brain proteins at 37/73 and 39/73. kDa. We explored the relationship between the presence of brain-specific autoantibodies and several behavioral characteristics of autism in 277 children with an autism spectrum disorder and 189 typically developing age-matched controls. Further, we used maternal autoantibody data to investigate potential familial relationships for the production of brain-directed autoantibodies. We demonstrated by Western blot that autoantibodies specific for a 45. kDa cerebellar protein in children were associated with a diagnosis of autism (p= 0.017) while autoantibodies directed towards a 62. kDa protein were associated with the broader diagnosis of autism spectrum disorder (ASD) (p= 0.043). Children with such autoantibodies had lower adaptive (p= 0.0008) and cognitive function (p= 0.005), as well as increased aberrant behaviors (p< 0.05) compared to children without these antibodies. No correlation was noted for those mothers with the most specific pattern of anti-fetal brain autoantibodies and children with the autoantibodies to either the 45 or 62. kDa bands. Collectively, these data suggest that antibodies towards brain proteins in children are associated with lower adaptive and cognitive function as well as core behaviors associated with autism. It is unclear whether these antibodies have direct pathologic significance, or if they are merely a response to previous injury. Future studies are needed to determine the identities of the protein targets and explore their significance in autism.

Original languageEnglish (US)
Pages (from-to)514-523
Number of pages10
JournalBrain, Behavior, and Immunity
Volume25
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Autistic Disorder
Autoantibodies
Cerebellum
Brain
Antibodies
Mothers
Proteins
Cognition
Fetal Proteins
Western Blotting
Wounds and Injuries

Keywords

  • Autism spectrum disorders
  • Autoantibody
  • Behavior
  • Brain
  • Cerebellum
  • Immune system
  • Immunoglobulin
  • Neurodevelopment

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Autoantibodies to cerebellum in children with autism associate with behavior. / Goines, Paula; Haapanen, Lori; Boyce, Robert; Duncanson, Paul; Braunschweig, Daniel; Delwiche, Lora; Hansen, Robin L; Hertz-Picciotto, Irva; Ashwood, Paul; Van de Water, Judith A.

In: Brain, Behavior, and Immunity, Vol. 25, No. 3, 03.2011, p. 514-523.

Research output: Contribution to journalArticle

Goines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L et al. Autoantibodies to cerebellum in children with autism associate with behavior. Brain, Behavior, and Immunity. 2011 Mar;25(3):514-523. https://doi.org/10.1016/j.bbi.2010.11.017
Goines, Paula ; Haapanen, Lori ; Boyce, Robert ; Duncanson, Paul ; Braunschweig, Daniel ; Delwiche, Lora ; Hansen, Robin L ; Hertz-Picciotto, Irva ; Ashwood, Paul ; Van de Water, Judith A. / Autoantibodies to cerebellum in children with autism associate with behavior. In: Brain, Behavior, and Immunity. 2011 ; Vol. 25, No. 3. pp. 514-523.
@article{d581a92983cb40c3a1467c3b13ce0119,
title = "Autoantibodies to cerebellum in children with autism associate with behavior",
abstract = "Autism is a heterogeneous disorder with a poorly understood biological basis. Some children with autism harbor plasma autoantibodies that target brain proteins. Similarly, some mothers of children with autism produce antibodies specific to autism that target pairs of fetal brain proteins at 37/73 and 39/73. kDa. We explored the relationship between the presence of brain-specific autoantibodies and several behavioral characteristics of autism in 277 children with an autism spectrum disorder and 189 typically developing age-matched controls. Further, we used maternal autoantibody data to investigate potential familial relationships for the production of brain-directed autoantibodies. We demonstrated by Western blot that autoantibodies specific for a 45. kDa cerebellar protein in children were associated with a diagnosis of autism (p= 0.017) while autoantibodies directed towards a 62. kDa protein were associated with the broader diagnosis of autism spectrum disorder (ASD) (p= 0.043). Children with such autoantibodies had lower adaptive (p= 0.0008) and cognitive function (p= 0.005), as well as increased aberrant behaviors (p< 0.05) compared to children without these antibodies. No correlation was noted for those mothers with the most specific pattern of anti-fetal brain autoantibodies and children with the autoantibodies to either the 45 or 62. kDa bands. Collectively, these data suggest that antibodies towards brain proteins in children are associated with lower adaptive and cognitive function as well as core behaviors associated with autism. It is unclear whether these antibodies have direct pathologic significance, or if they are merely a response to previous injury. Future studies are needed to determine the identities of the protein targets and explore their significance in autism.",
keywords = "Autism spectrum disorders, Autoantibody, Behavior, Brain, Cerebellum, Immune system, Immunoglobulin, Neurodevelopment",
author = "Paula Goines and Lori Haapanen and Robert Boyce and Paul Duncanson and Daniel Braunschweig and Lora Delwiche and Hansen, {Robin L} and Irva Hertz-Picciotto and Paul Ashwood and {Van de Water}, {Judith A}",
year = "2011",
month = "3",
doi = "10.1016/j.bbi.2010.11.017",
language = "English (US)",
volume = "25",
pages = "514--523",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Autoantibodies to cerebellum in children with autism associate with behavior

AU - Goines, Paula

AU - Haapanen, Lori

AU - Boyce, Robert

AU - Duncanson, Paul

AU - Braunschweig, Daniel

AU - Delwiche, Lora

AU - Hansen, Robin L

AU - Hertz-Picciotto, Irva

AU - Ashwood, Paul

AU - Van de Water, Judith A

PY - 2011/3

Y1 - 2011/3

N2 - Autism is a heterogeneous disorder with a poorly understood biological basis. Some children with autism harbor plasma autoantibodies that target brain proteins. Similarly, some mothers of children with autism produce antibodies specific to autism that target pairs of fetal brain proteins at 37/73 and 39/73. kDa. We explored the relationship between the presence of brain-specific autoantibodies and several behavioral characteristics of autism in 277 children with an autism spectrum disorder and 189 typically developing age-matched controls. Further, we used maternal autoantibody data to investigate potential familial relationships for the production of brain-directed autoantibodies. We demonstrated by Western blot that autoantibodies specific for a 45. kDa cerebellar protein in children were associated with a diagnosis of autism (p= 0.017) while autoantibodies directed towards a 62. kDa protein were associated with the broader diagnosis of autism spectrum disorder (ASD) (p= 0.043). Children with such autoantibodies had lower adaptive (p= 0.0008) and cognitive function (p= 0.005), as well as increased aberrant behaviors (p< 0.05) compared to children without these antibodies. No correlation was noted for those mothers with the most specific pattern of anti-fetal brain autoantibodies and children with the autoantibodies to either the 45 or 62. kDa bands. Collectively, these data suggest that antibodies towards brain proteins in children are associated with lower adaptive and cognitive function as well as core behaviors associated with autism. It is unclear whether these antibodies have direct pathologic significance, or if they are merely a response to previous injury. Future studies are needed to determine the identities of the protein targets and explore their significance in autism.

AB - Autism is a heterogeneous disorder with a poorly understood biological basis. Some children with autism harbor plasma autoantibodies that target brain proteins. Similarly, some mothers of children with autism produce antibodies specific to autism that target pairs of fetal brain proteins at 37/73 and 39/73. kDa. We explored the relationship between the presence of brain-specific autoantibodies and several behavioral characteristics of autism in 277 children with an autism spectrum disorder and 189 typically developing age-matched controls. Further, we used maternal autoantibody data to investigate potential familial relationships for the production of brain-directed autoantibodies. We demonstrated by Western blot that autoantibodies specific for a 45. kDa cerebellar protein in children were associated with a diagnosis of autism (p= 0.017) while autoantibodies directed towards a 62. kDa protein were associated with the broader diagnosis of autism spectrum disorder (ASD) (p= 0.043). Children with such autoantibodies had lower adaptive (p= 0.0008) and cognitive function (p= 0.005), as well as increased aberrant behaviors (p< 0.05) compared to children without these antibodies. No correlation was noted for those mothers with the most specific pattern of anti-fetal brain autoantibodies and children with the autoantibodies to either the 45 or 62. kDa bands. Collectively, these data suggest that antibodies towards brain proteins in children are associated with lower adaptive and cognitive function as well as core behaviors associated with autism. It is unclear whether these antibodies have direct pathologic significance, or if they are merely a response to previous injury. Future studies are needed to determine the identities of the protein targets and explore their significance in autism.

KW - Autism spectrum disorders

KW - Autoantibody

KW - Behavior

KW - Brain

KW - Cerebellum

KW - Immune system

KW - Immunoglobulin

KW - Neurodevelopment

UR - http://www.scopus.com/inward/record.url?scp=79551687313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551687313&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2010.11.017

DO - 10.1016/j.bbi.2010.11.017

M3 - Article

C2 - 21134442

AN - SCOPUS:79551687313

VL - 25

SP - 514

EP - 523

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

IS - 3

ER -