Autoantibodies in Autism Spectrum Disorders (ASD)

Sharifia Wills, Maricel Cabanlit, Jeff Bennett, Paul Ashwood, David G Amaral, Judith A Van de Water

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

66 Scopus citations

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders defined behaviorally by abnormalities in social, verbal, and nonverbal communication. The etiologies of ASD are unknown, likely to be the result of a variety of numerous genetic, neurological, environmental, and immunological interactions that lead to a general behavioral phenotype defined as ASD. This review will focus on the various immune system anomalies, in particular, autoantibodies, which have been reported in subjects with ASD. In addition, we will discuss recent studies performed by our group concerning the presence of autoantibodies directed against neural antigens, which are observed in patients with ASD.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages79-91
Number of pages13
Volume1107
DOIs
StatePublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1107
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • ASD
  • Autism
  • Autoantibodies
  • Brain
  • Immune system
  • Immunity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. A. (2007). Autoantibodies in Autism Spectrum Disorders (ASD). In Annals of the New York Academy of Sciences (Vol. 1107, pp. 79-91). (Annals of the New York Academy of Sciences; Vol. 1107). https://doi.org/10.1196/annals.1381.009