Autoantibodies in Autism Spectrum Disorders (ASD)

Sharifia Wills; Maricel Cabanlit; Jeff Bennett; Paul Ashwood; David Amaral; Judy Van De Water

doi:10.1196/annals.1381.009

Autoantibodies in Autism Spectrum Disorders (ASD)

Sharifia Wills, Maricel Cabanlit, Jeff Bennett, Paul Ashwood, David Amaral, Judy Van De Water

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

70 Scopus citations

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders defined behaviorally by abnormalities in social, verbal, and nonverbal communication. The etiologies of ASD are unknown, likely to be the result of a variety of numerous genetic, neurological, environmental, and immunological interactions that lead to a general behavioral phenotype defined as ASD. This review will focus on the various immune system anomalies, in particular, autoantibodies, which have been reported in subjects with ASD. In addition, we will discuss recent studies performed by our group concerning the presence of autoantibodies directed against neural antigens, which are observed in patients with ASD.

Original language	English (US)
Title of host publication	Annals of the New York Academy of Sciences
Pages	79-91
Number of pages	13
Volume	1107
DOIs	https://doi.org/10.1196/annals.1381.009
State	Published - Jun 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1107
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

ASD
Autism
Autoantibodies
Brain
Immune system
Immunity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1196/annals.1381.009

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title = "Autoantibodies in Autism Spectrum Disorders (ASD)",

abstract = "Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders defined behaviorally by abnormalities in social, verbal, and nonverbal communication. The etiologies of ASD are unknown, likely to be the result of a variety of numerous genetic, neurological, environmental, and immunological interactions that lead to a general behavioral phenotype defined as ASD. This review will focus on the various immune system anomalies, in particular, autoantibodies, which have been reported in subjects with ASD. In addition, we will discuss recent studies performed by our group concerning the presence of autoantibodies directed against neural antigens, which are observed in patients with ASD.",

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AU - Wills, Sharifia

AU - Cabanlit, Maricel

AU - Bennett, Jeff

AU - Ashwood, Paul

AU - Amaral, David

AU - Van De Water, Judy

PY - 2007/6

Y1 - 2007/6

N2 - Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders defined behaviorally by abnormalities in social, verbal, and nonverbal communication. The etiologies of ASD are unknown, likely to be the result of a variety of numerous genetic, neurological, environmental, and immunological interactions that lead to a general behavioral phenotype defined as ASD. This review will focus on the various immune system anomalies, in particular, autoantibodies, which have been reported in subjects with ASD. In addition, we will discuss recent studies performed by our group concerning the presence of autoantibodies directed against neural antigens, which are observed in patients with ASD.

AB - Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders defined behaviorally by abnormalities in social, verbal, and nonverbal communication. The etiologies of ASD are unknown, likely to be the result of a variety of numerous genetic, neurological, environmental, and immunological interactions that lead to a general behavioral phenotype defined as ASD. This review will focus on the various immune system anomalies, in particular, autoantibodies, which have been reported in subjects with ASD. In addition, we will discuss recent studies performed by our group concerning the presence of autoantibodies directed against neural antigens, which are observed in patients with ASD.

KW - ASD

KW - Autism

KW - Autoantibodies

KW - Brain

KW - Immune system

KW - Immunity

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DO - 10.1196/annals.1381.009

M3 - Conference contribution

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BT - Annals of the New York Academy of Sciences

ER -

Autoantibodies in Autism Spectrum Disorders (ASD)

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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