Autistic traits in epilepsy models: Why, when and how?

Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre Pascal Lenck-Santini

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models. We then discuss two of the potential pathological processes that could be shared between ASD and epilepsy. We first focus on functional implications of neuroinflammation including changes to excitable networks mediated by inflammatory regulators. Finally we examine mechanisms at the cellular and network level involved in neuronal excitability, timing and network coordination that may directly lead to behavioral disturbances present in both epilepsy and ASD. This mini-review summarizes the work first presented at an Investigators Workshop at the 2016 American Epilepsy Society meeting.

Original languageEnglish (US)
Pages (from-to)62-70
Number of pages9
JournalEpilepsy Research
Volume144
DOIs
StatePublished - Aug 1 2018

Fingerprint

Epilepsy
Seizures
Pathologic Processes
Comorbidity
Animal Models
Research Personnel
Autism Spectrum Disorder
Education
Research

Keywords

  • Autism spectrum disorder
  • Behavioral assays
  • Epilepsy comorbidity
  • Excitation-inhibition balance
  • Network coordination
  • Neuroinflammation
  • Novel mechanisms
  • Seizures
  • Translation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Autistic traits in epilepsy models : Why, when and how? / Velíšková, Jana; Silverman, Jill L; Benson, Melissa; Lenck-Santini, Pierre Pascal.

In: Epilepsy Research, Vol. 144, 01.08.2018, p. 62-70.

Research output: Contribution to journalReview article

Velíšková, Jana ; Silverman, Jill L ; Benson, Melissa ; Lenck-Santini, Pierre Pascal. / Autistic traits in epilepsy models : Why, when and how?. In: Epilepsy Research. 2018 ; Vol. 144. pp. 62-70.
@article{268216a13cd14ced96a7194a45af6ff4,
title = "Autistic traits in epilepsy models: Why, when and how?",
abstract = "Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models. We then discuss two of the potential pathological processes that could be shared between ASD and epilepsy. We first focus on functional implications of neuroinflammation including changes to excitable networks mediated by inflammatory regulators. Finally we examine mechanisms at the cellular and network level involved in neuronal excitability, timing and network coordination that may directly lead to behavioral disturbances present in both epilepsy and ASD. This mini-review summarizes the work first presented at an Investigators Workshop at the 2016 American Epilepsy Society meeting.",
keywords = "Autism spectrum disorder, Behavioral assays, Epilepsy comorbidity, Excitation-inhibition balance, Network coordination, Neuroinflammation, Novel mechanisms, Seizures, Translation",
author = "Jana Vel{\'i}škov{\'a} and Silverman, {Jill L} and Melissa Benson and Lenck-Santini, {Pierre Pascal}",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.eplepsyres.2018.05.009",
language = "English (US)",
volume = "144",
pages = "62--70",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

TY - JOUR

T1 - Autistic traits in epilepsy models

T2 - Why, when and how?

AU - Velíšková, Jana

AU - Silverman, Jill L

AU - Benson, Melissa

AU - Lenck-Santini, Pierre Pascal

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models. We then discuss two of the potential pathological processes that could be shared between ASD and epilepsy. We first focus on functional implications of neuroinflammation including changes to excitable networks mediated by inflammatory regulators. Finally we examine mechanisms at the cellular and network level involved in neuronal excitability, timing and network coordination that may directly lead to behavioral disturbances present in both epilepsy and ASD. This mini-review summarizes the work first presented at an Investigators Workshop at the 2016 American Epilepsy Society meeting.

AB - Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models. We then discuss two of the potential pathological processes that could be shared between ASD and epilepsy. We first focus on functional implications of neuroinflammation including changes to excitable networks mediated by inflammatory regulators. Finally we examine mechanisms at the cellular and network level involved in neuronal excitability, timing and network coordination that may directly lead to behavioral disturbances present in both epilepsy and ASD. This mini-review summarizes the work first presented at an Investigators Workshop at the 2016 American Epilepsy Society meeting.

KW - Autism spectrum disorder

KW - Behavioral assays

KW - Epilepsy comorbidity

KW - Excitation-inhibition balance

KW - Network coordination

KW - Neuroinflammation

KW - Novel mechanisms

KW - Seizures

KW - Translation

UR - http://www.scopus.com/inward/record.url?scp=85047072548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047072548&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2018.05.009

DO - 10.1016/j.eplepsyres.2018.05.009

M3 - Review article

C2 - 29783181

AN - SCOPUS:85047072548

VL - 144

SP - 62

EP - 70

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -