Autism Symptoms in Fragile X Syndrome

Manman Niu, Ying Han, Angel Belle C. Dy, Junbao Du, Hongfang Jin, Jiong Qin, Jing Zhang, Qinrui Li, Randi J Hagerman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Fragile X syndrome (FXS) is recognized as the most common genetic cause of intellectual disability and autism spectrum disorder (ASD). Although symptoms of ASD are frequently observed in patients with FXS, researchers have not yet clearly determined whether the symptoms in patients with FXS differ from the symptoms in patients without ASD or nonsyndromic ASD. Behavioral similarities and differences between FXS and ASD are important to improve our understanding of the causes and correlations of ASD with FXS. Based on the evidence presented in this review, individuals with FXS and comorbid ASD have more severe behavioral problems than individuals with FXS alone. However, patients with FXS and comorbid ASD exhibit less severe impairments in the social and communication symptoms than patients with nonsyndromic ASD. Individuals with FXS also present with anxiety and seizures in addition to comorbid ASD symptoms, and differences in these conditions are noted in patients with FXS and ASD. This review also discusses the role of fragile X mental retardation 1 protein (FMRP) in FXS and ASD phenotypes.

Original languageEnglish (US)
Pages (from-to)903-909
Number of pages7
JournalJournal of Child Neurology
Volume32
Issue number10
DOIs
StatePublished - Sep 1 2017

Keywords

  • anxiety
  • autism spectrum disorder
  • fragile X mental retardation 1 protein
  • fragile X syndrome
  • seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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  • Cite this

    Niu, M., Han, Y., Dy, A. B. C., Du, J., Jin, H., Qin, J., Zhang, J., Li, Q., & Hagerman, R. J. (2017). Autism Symptoms in Fragile X Syndrome. Journal of Child Neurology, 32(10), 903-909. https://doi.org/10.1177/0883073817712875