TY - JOUR
T1 - Autism Symptomatology in Boys with Fragile X Syndrome
T2 - A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder
AU - Thurman, Angela John
AU - McDuffie, Andrea
AU - Kover, Sara T.
AU - Hagerman, Randi J
AU - Abbeduto, Leonard J
PY - 2015/4/23
Y1 - 2015/4/23
N2 - Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.
AB - Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.
KW - Autism spectrum disorder
KW - Behavioral phenotype
KW - Developmental trajectory
KW - Expressive vocabulary
KW - Fragile X syndrome
KW - Nonverbal cognition
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U2 - 10.1007/s10803-015-2443-4
DO - 10.1007/s10803-015-2443-4
M3 - Article
C2 - 25904201
AN - SCOPUS:84941421550
VL - 45
SP - 2816
EP - 2832
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 9
ER -