Autism spectrum disorder in children and adolescents with fragile X syndrome: Within-syndrome differences and age-related changes

Andrea McDuffie, Leonard J Abbeduto, Pamela Lewis, Sara Kover, Jee Seon Kim, Ann Weber, W. Ted Brown

Research output: Contribution to journalArticle

66 Scopus citations


The Autism Diagnostic Interview-Revised (ADI-R) was used to examine diagnostic profiles and age-related changes in autism symptoms for a group of verbal children and adolescents who had fragile X syndrome, with and without autism. After controlling for nonverbal IQ, we found statistically significant between-group differences for lifetime and current autism symptoms for the Communication and Restricted Interests/Repetitive Behaviors domains, but not the Reciprocal Social Interaction domain. Effect sizes for differences in Reciprocal Social Interaction also were smaller than effect sizes for the other domains, with one exception. Overall, severity of autism symptoms improved with age for all participants, with the least improvement noted for Restricted Interests and Repetitive Behaviors. FMRP did not account for unique variance in autism symptoms over and above nonverbal IQ.

Original languageEnglish (US)
Pages (from-to)307-326
Number of pages20
JournalAmerican Journal on Intellectual and Developmental Disabilities
Issue number4
StatePublished - Jul 2010
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

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