Autism, regression, and the broader autism phenotype

Janet E. Lainhart, Sally J Ozonoff, Hilary Coon, Lori Krasny, Elena Dinh, Julie Nice, William McMahon

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The broader autism phenotype (BAP) is a subclinical set of personality and other features that is thought to index familiality and/or genetic liability to autism. Eighteen parents of autistic probands with a history of language regression and 70 parents of autistic probands without regression were assessed for features of the BAP and compared with published rates in parents of nonautistic subjects. Parents of probands with regressive and nonregressive autism demonstrated similar rates of the BAP (27.8% vs. 32.9%; P = 0.33). The rate of the BAP was significantly higher in both groups of autism parents than in parents of nonautistic subjects (P ≤ 0.01). Thus, this measure of genetic liability is increased equally in families with both forms of autism when compared with controls. Environmental events are therefore unlikely to be the sole cause of regressive autism in our sample. Environmental events, however, may act in an additive or "second-hit" fashion in individuals with a genetic vulnerability to autism.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalAmerican Journal of Medical Genetics
Volume113
Issue number3
DOIs
StatePublished - Dec 1 2002

Keywords

  • Autism
  • Broader autism phenotype
  • Environment
  • Regression

ASJC Scopus subject areas

  • Genetics(clinical)

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    Lainhart, J. E., Ozonoff, S. J., Coon, H., Krasny, L., Dinh, E., Nice, J., & McMahon, W. (2002). Autism, regression, and the broader autism phenotype. American Journal of Medical Genetics, 113(3), 231-237. https://doi.org/10.1002/ajmg.10615