Autism profiles of males with fragile X syndrome

Susan W. Harris, David R Hessl, Beth Goodlin-Jones, Jessica A Ferranti, Susan Bacalman, Ingrid Barbato, Flora Tassone, Paul J Hagerman, Kristin Herman, Randi J Hagerman

Research output: Contribution to journalArticle

255 Scopus citations

Abstract

Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number.

Original languageEnglish (US)
Pages (from-to)427-438
Number of pages12
JournalAmerican Journal on Mental Retardation
Volume113
Issue number6
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Rehabilitation
  • Developmental and Educational Psychology

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