Autism in fragile X females

Randi J Hagerman, A. E. Chudley, J. H. Knoll, A. W. Jackson, M. Kemper, R. Ahmad

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We present two women with the fragile X syndrome (Martin-Bell syndrome) and autism. Both are mentally retarded, one mildly and one severely. Cytogenetic studies showed a high percentage of lymphocytes with the fragile X chromosome and inactivation occurring preferentially in the normal X chromosome. Autism is shown to be a severe behavioral and cognitive manifestation of the fragile X syndrome in females.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume23
Issue number1-2
StatePublished - 1986
Externally publishedYes

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Fragile X Syndrome
Autistic Disorder
X Chromosome Inactivation
Neurobehavioral Manifestations
Mentally Disabled Persons
X Chromosome
Cytogenetics
Lymphocytes

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Hagerman, R. J., Chudley, A. E., Knoll, J. H., Jackson, A. W., Kemper, M., & Ahmad, R. (1986). Autism in fragile X females. American Journal of Medical Genetics, 23(1-2), 375-380.

Autism in fragile X females. / Hagerman, Randi J; Chudley, A. E.; Knoll, J. H.; Jackson, A. W.; Kemper, M.; Ahmad, R.

In: American Journal of Medical Genetics, Vol. 23, No. 1-2, 1986, p. 375-380.

Research output: Contribution to journalArticle

Hagerman, RJ, Chudley, AE, Knoll, JH, Jackson, AW, Kemper, M & Ahmad, R 1986, 'Autism in fragile X females', American Journal of Medical Genetics, vol. 23, no. 1-2, pp. 375-380.
Hagerman RJ, Chudley AE, Knoll JH, Jackson AW, Kemper M, Ahmad R. Autism in fragile X females. American Journal of Medical Genetics. 1986;23(1-2):375-380.
Hagerman, Randi J ; Chudley, A. E. ; Knoll, J. H. ; Jackson, A. W. ; Kemper, M. ; Ahmad, R. / Autism in fragile X females. In: American Journal of Medical Genetics. 1986 ; Vol. 23, No. 1-2. pp. 375-380.
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