Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Jacqueline Crawley, Wolf Dietrich Heyer, Janine M LaSalle

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalTrends in Genetics
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Autism
  • Cancer
  • Chromatin remodeling
  • DNA repair
  • Gene
  • Signaling pathway

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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