Augmented antitumor effects of combination therapy with interleukin-12, cisplatin, and tumor necrosis factor-α in a murine melanoma model

Radosław Zagozdzon, Tomasz Stokłosa, Jakub Gołab, Adam Giermasz, Anna Dabrowska, Witold Lasek, Marek Jakóbisiak

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Interleukin-12 (IL-12) has demonstrated antitumor activity in many murine tumor models. However, toxic effects resulting from treatment with IL-12 have been also described. Combining IL-12 with other antineoplastic agents could potentiate its antitumor efficacy and, furthermore, could minimize its toxicity by reducing the doses necessary to achieve the antitumor activity. We examined in a murine melanoma model the efficacy of combination tumor chemo-immunotherapy based on administration of IL-12, cisplatin (CDDP), and tumor necrosis factor-α (TNF-α). In the current study pairs of IL-12 + CDDP and IL-12 + TNF-α, showed stronger antitumor activity than either agent given alone. Furthermore, combination tumor therapy with IL-12 + CDDP + TNF-α was more effective at retarding local tumor growth than either IL-12 + CDDP, IL-12 + TNF-α or CDDP + TNF-α combination therapies. Our observations indicate that combining of CDDP with IL-12 and IL-12 with TNF-α as well as using the triple combination of CDDP, IL-12 and TNF-α could be beneficial in tumor therapy.

Original languageEnglish (US)
Pages (from-to)4493-4498
Number of pages6
JournalAnticancer Research
Volume17
Issue number6 D
StatePublished - Nov 1997
Externally publishedYes

Keywords

  • Cisplatin
  • Interleukin-12
  • Melanoma
  • Mice
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zagozdzon, R., Stokłosa, T., Gołab, J., Giermasz, A., Dabrowska, A., Lasek, W., & Jakóbisiak, M. (1997). Augmented antitumor effects of combination therapy with interleukin-12, cisplatin, and tumor necrosis factor-α in a murine melanoma model. Anticancer Research, 17(6 D), 4493-4498.