Augmentation of the exercise pressor reflex in prehypertension

Roles of the muscle metaboreflex and mechanoreflex

Hyun Min Choi, Charles L Stebbins, Og Taeg Lee, Hosung Nho, Joon Hee Lee, Jong Mok Chun, Kyung Ae Kim, Jong Kyung Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This study investigated the hemodynamic mechanisms underlying the exaggerated blood pressure response to muscle contraction in prehypertensive humans and the potential role of skeletal muscle metabo- and mechanoreceptors in this response. To accomplish this, changes in peak mean arterial blood pressure (δMAP), cardiac output, and total peripheral resistance (δTPR) were compared between prehypertensive (n = 23) and normotensive (n = 19) male subjects during 2 min of static contraction (at 50% of maximal tension), 2 min of postexercise muscle ischemia (metaboreflex), and 1 min of passive dorsiflexion of the foot (tendon stretch, mechanoreceptor reflex). These variables were assessed before and during the interventions. Percentage increases from baseline in MAP and TPR in response to the exercise pressor reflex were augmented in the prehypertensives, compared with the normotensives (44% ± 5% vs. 33% ± 4% and 34% ± 15% vs. 2% ± 8%, respectively) (p < 0.05). Metaboreflex-induced increases in MAP and TPR were also augmented in the prehypertensives (28% ± 5% vs. 14% ± 4% and 36% ± 12% vs. 14% ± 9%, respectively) (p < 0.05). In response to the mechanoreflex, no differences in the percentage increase in MAP or TPR were seen between groups. The results indicate that the reflex pressor response to static contraction is augmented in prehypertension and suggest that this phenomenon is due, at least in part, to enhanced activation of metaboreceptors.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalApplied Physiology, Nutrition and Metabolism
Volume38
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Prehypertension
Reflex
Arterial Pressure
Muscles
Vascular Resistance
Mechanoreceptors
Stretch Reflex
Muscle Contraction
Cardiac Output
Tendons
Foot
Skeletal Muscle
Ischemia
Hemodynamics
Blood Pressure

Keywords

  • Exercise pressor reflex
  • Postexercise muscle ischemia
  • Total vascular conductance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

Augmentation of the exercise pressor reflex in prehypertension : Roles of the muscle metaboreflex and mechanoreflex. / Choi, Hyun Min; Stebbins, Charles L; Lee, Og Taeg; Nho, Hosung; Lee, Joon Hee; Chun, Jong Mok; Kim, Kyung Ae; Kim, Jong Kyung.

In: Applied Physiology, Nutrition and Metabolism, Vol. 38, No. 2, 02.2013, p. 209-215.

Research output: Contribution to journalArticle

Choi, Hyun Min ; Stebbins, Charles L ; Lee, Og Taeg ; Nho, Hosung ; Lee, Joon Hee ; Chun, Jong Mok ; Kim, Kyung Ae ; Kim, Jong Kyung. / Augmentation of the exercise pressor reflex in prehypertension : Roles of the muscle metaboreflex and mechanoreflex. In: Applied Physiology, Nutrition and Metabolism. 2013 ; Vol. 38, No. 2. pp. 209-215.
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