Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid

Richard V Perez, R. Munda, J. W. Alexander

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Increased prostaglandin production is a possible mechanism for the immunosuppressive effects of both cyclosporine and blood transfusions. Therefore, dietary supplementation with linoleic acid, a prostaglandin precursor, combined with either modality could act synergistically. Intraabdominal cardiac allografts were performed from Buffalo rat donors to Lewis recipients. Transplant recipients received a single donor-specific transfusion, low-dose cyclosporine (CsA, 1 mg/kd/d x 7 days), dietary supplementation with linoleic acid (LA, 16% of total calories) or a combination of the three modalities. CsA, DST or LA alone significantly prolonged allograft survival. Both CsA and LA acted synergistically with DST in further prolongation of survival - however, animals receiving all three modalities achieved 100% long-term survival. Augmentation of transfusion- and cyclosporine-induced immunosuppression with dietary prostaglandin precursor is possible.

Original languageEnglish (US)
Pages (from-to)937-940
Number of pages4
JournalTransplantation
Volume47
Issue number6
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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