Abstract
Increased prostaglandin production is a possible mechanism for the immunosuppressive effects of both cyclosporine and blood transfusions. Therefore, dietary supplementation with linoleic acid, a prostaglandin precursor, combined with either modality could act synergistically. Intraabdominal cardiac allografts were performed from Buffalo rat donors to Lewis recipients. Transplant recipients received a single donor-specific transfusion, low-dose cyclosporine (CsA, 1 mg/kd/d x 7 days), dietary supplementation with linoleic acid (LA, 16% of total calories) or a combination of the three modalities. CsA, DST or LA alone significantly prolonged allograft survival. Both CsA and LA acted synergistically with DST in further prolongation of survival - however, animals receiving all three modalities achieved 100% long-term survival. Augmentation of transfusion- and cyclosporine-induced immunosuppression with dietary prostaglandin precursor is possible.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 937-940 |
| Number of pages | 4 |
| Journal | Transplantation |
| Volume | 47 |
| Issue number | 6 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Transplantation
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Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid. / Perez, Richard V; Munda, R.; Alexander, J. W.
In: Transplantation, Vol. 47, No. 6, 1989, p. 937-940.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid
AU - Perez, Richard V
AU - Munda, R.
AU - Alexander, J. W.
PY - 1989
Y1 - 1989
N2 - Increased prostaglandin production is a possible mechanism for the immunosuppressive effects of both cyclosporine and blood transfusions. Therefore, dietary supplementation with linoleic acid, a prostaglandin precursor, combined with either modality could act synergistically. Intraabdominal cardiac allografts were performed from Buffalo rat donors to Lewis recipients. Transplant recipients received a single donor-specific transfusion, low-dose cyclosporine (CsA, 1 mg/kd/d x 7 days), dietary supplementation with linoleic acid (LA, 16% of total calories) or a combination of the three modalities. CsA, DST or LA alone significantly prolonged allograft survival. Both CsA and LA acted synergistically with DST in further prolongation of survival - however, animals receiving all three modalities achieved 100% long-term survival. Augmentation of transfusion- and cyclosporine-induced immunosuppression with dietary prostaglandin precursor is possible.
AB - Increased prostaglandin production is a possible mechanism for the immunosuppressive effects of both cyclosporine and blood transfusions. Therefore, dietary supplementation with linoleic acid, a prostaglandin precursor, combined with either modality could act synergistically. Intraabdominal cardiac allografts were performed from Buffalo rat donors to Lewis recipients. Transplant recipients received a single donor-specific transfusion, low-dose cyclosporine (CsA, 1 mg/kd/d x 7 days), dietary supplementation with linoleic acid (LA, 16% of total calories) or a combination of the three modalities. CsA, DST or LA alone significantly prolonged allograft survival. Both CsA and LA acted synergistically with DST in further prolongation of survival - however, animals receiving all three modalities achieved 100% long-term survival. Augmentation of transfusion- and cyclosporine-induced immunosuppression with dietary prostaglandin precursor is possible.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024346138&partnerID=8YFLogxK
M3 - Article
C2 - 2660353
AN - SCOPUS:0024346138
VL - 47
SP - 937
EP - 940
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 6
ER -