Audiogenic seizure susceptibility and auditory brainstem responses in rats prenatally exposed to alcohol

Robert F Berman, D. J. Beare, M. W. Church, E. L. Abel

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Rats prenatally exposed to alcohol (0%, 17.5%, or 35% ethanol-derived calories) were tested for audiogenic seizure susceptibility on one of postnatal days 18 to 23, then retested 5 days later. Prenatal alcohol exposure did not influence audiogenic seizure susceptibility or severity. There was, however, a significant increase in seizure incidence on the retest day for all groups, suggesting a priming effect. Auditory brainstem response (ABR) data suggested that prenatal alcohol exposure and acoustic trauma (i.e., exposure to an alarm bell used for eliciting audiogenic seizures) induced measurable sensorineural hearing loss, and that the combined exposure to alcohol and acoustic trauma interacted additively to produce greater hearing loss than either alone.

Original languageEnglish (US)
Pages (from-to)490-498
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Acoustic Priming
  • Audiogenic Seizures
  • Auditory Brainstem Responses
  • Prenatal Alcohol Exposure

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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