Atypical functional brain activation during a multiple object tracking task in girls with turner syndrome

Neurocorrelates of reduced spatiotemporal resolution

Elliott A. Beaton, Joel Stoddard, Song Lai, John Lackey, Jianrong Shi, Judith L. Ross, Tony J Simon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Turner syndrome is associated with spatial and numerical cognitive impairments. We hypothesized that these nonverbal cognitive impairments result from limits in spatial and temporal processing, particularly as it affects attention. To examine spatiotemporal attention in girls with Turner syndrome versus typically developing controls, we used a multiple object tracking task during functional magnetic resonance (fMRI) imaging. Participants actively tracked a target among six distracters or passively viewed the animations. Neural activation in girls with Turner syndrome during object tracking overlapped with but was dissimilar to the canonical frontoparietal network evident in typically developing controls and included greater limbic activity. Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome.

Original languageEnglish (US)
Pages (from-to)140-156
Number of pages17
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume115
Issue number2
DOIs
StatePublished - Mar 2010

Fingerprint

Turner Syndrome
Brain
Magnetic Resonance Imaging
Task Performance and Analysis
Brain Activation
Multiple Object Tracking
Spatial Processing
Cognitive Dysfunction
Cognitive Impairment
Activation

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

Cite this

Atypical functional brain activation during a multiple object tracking task in girls with turner syndrome : Neurocorrelates of reduced spatiotemporal resolution. / Beaton, Elliott A.; Stoddard, Joel; Lai, Song; Lackey, John; Shi, Jianrong; Ross, Judith L.; Simon, Tony J.

In: American Journal on Intellectual and Developmental Disabilities, Vol. 115, No. 2, 03.2010, p. 140-156.

Research output: Contribution to journalArticle

@article{b9190c028b2b4edaa847bc6b5f9664f9,
title = "Atypical functional brain activation during a multiple object tracking task in girls with turner syndrome: Neurocorrelates of reduced spatiotemporal resolution",
abstract = "Turner syndrome is associated with spatial and numerical cognitive impairments. We hypothesized that these nonverbal cognitive impairments result from limits in spatial and temporal processing, particularly as it affects attention. To examine spatiotemporal attention in girls with Turner syndrome versus typically developing controls, we used a multiple object tracking task during functional magnetic resonance (fMRI) imaging. Participants actively tracked a target among six distracters or passively viewed the animations. Neural activation in girls with Turner syndrome during object tracking overlapped with but was dissimilar to the canonical frontoparietal network evident in typically developing controls and included greater limbic activity. Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome.",
author = "Beaton, {Elliott A.} and Joel Stoddard and Song Lai and John Lackey and Jianrong Shi and Ross, {Judith L.} and Simon, {Tony J}",
year = "2010",
month = "3",
doi = "10.1352/1944-7558-115.2.140",
language = "English (US)",
volume = "115",
pages = "140--156",
journal = "American Journal on Intellectual and Developmental Disabilities",
issn = "1944-7558",
publisher = "American Association on Intellectual and Developmental Disabilities",
number = "2",

}

TY - JOUR

T1 - Atypical functional brain activation during a multiple object tracking task in girls with turner syndrome

T2 - Neurocorrelates of reduced spatiotemporal resolution

AU - Beaton, Elliott A.

AU - Stoddard, Joel

AU - Lai, Song

AU - Lackey, John

AU - Shi, Jianrong

AU - Ross, Judith L.

AU - Simon, Tony J

PY - 2010/3

Y1 - 2010/3

N2 - Turner syndrome is associated with spatial and numerical cognitive impairments. We hypothesized that these nonverbal cognitive impairments result from limits in spatial and temporal processing, particularly as it affects attention. To examine spatiotemporal attention in girls with Turner syndrome versus typically developing controls, we used a multiple object tracking task during functional magnetic resonance (fMRI) imaging. Participants actively tracked a target among six distracters or passively viewed the animations. Neural activation in girls with Turner syndrome during object tracking overlapped with but was dissimilar to the canonical frontoparietal network evident in typically developing controls and included greater limbic activity. Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome.

AB - Turner syndrome is associated with spatial and numerical cognitive impairments. We hypothesized that these nonverbal cognitive impairments result from limits in spatial and temporal processing, particularly as it affects attention. To examine spatiotemporal attention in girls with Turner syndrome versus typically developing controls, we used a multiple object tracking task during functional magnetic resonance (fMRI) imaging. Participants actively tracked a target among six distracters or passively viewed the animations. Neural activation in girls with Turner syndrome during object tracking overlapped with but was dissimilar to the canonical frontoparietal network evident in typically developing controls and included greater limbic activity. Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome.

UR - http://www.scopus.com/inward/record.url?scp=77952752529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952752529&partnerID=8YFLogxK

U2 - 10.1352/1944-7558-115.2.140

DO - 10.1352/1944-7558-115.2.140

M3 - Article

VL - 115

SP - 140

EP - 156

JO - American Journal on Intellectual and Developmental Disabilities

JF - American Journal on Intellectual and Developmental Disabilities

SN - 1944-7558

IS - 2

ER -