Attenuation of exposure-response curves in occupational cohort studies at high exposure levels

Leslie Stayner, Kyle Steenland, Mustafa Dosemeci, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalScandinavian Journal of Work, Environment and Health
Volume29
Issue number4
StatePublished - Aug 2003

Fingerprint

Cohort Studies
Healthy Worker Effect
Radon Daughters
Beryllium
Disease
Fumes
Dioxins
Arsenic
Nickel
Cadmium
Silicon Dioxide
Survivors
mortality
worker
Mortality
Enzymes
trend
Population
beryllium
radon

Keywords

  • Epidemiology
  • Flat dose-response

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

Cite this

Attenuation of exposure-response curves in occupational cohort studies at high exposure levels. / Stayner, Leslie; Steenland, Kyle; Dosemeci, Mustafa; Hertz-Picciotto, Irva.

In: Scandinavian Journal of Work, Environment and Health, Vol. 29, No. 4, 08.2003, p. 317-324.

Research output: Contribution to journalArticle

@article{10a580f1a55742cc942297378d09fc1a,
title = "Attenuation of exposure-response curves in occupational cohort studies at high exposure levels",
abstract = "Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease.",
keywords = "Epidemiology, Flat dose-response",
author = "Leslie Stayner and Kyle Steenland and Mustafa Dosemeci and Irva Hertz-Picciotto",
year = "2003",
month = "8",
language = "English (US)",
volume = "29",
pages = "317--324",
journal = "Scandinavian Journal of Work, Environment and Health",
issn = "0355-3140",
publisher = "Finnish Institute of Occupational Health",
number = "4",

}

TY - JOUR

T1 - Attenuation of exposure-response curves in occupational cohort studies at high exposure levels

AU - Stayner, Leslie

AU - Steenland, Kyle

AU - Dosemeci, Mustafa

AU - Hertz-Picciotto, Irva

PY - 2003/8

Y1 - 2003/8

N2 - Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease.

AB - Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease.

KW - Epidemiology

KW - Flat dose-response

UR - http://www.scopus.com/inward/record.url?scp=0041508916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041508916&partnerID=8YFLogxK

M3 - Article

C2 - 12934726

AN - SCOPUS:0041508916

VL - 29

SP - 317

EP - 324

JO - Scandinavian Journal of Work, Environment and Health

JF - Scandinavian Journal of Work, Environment and Health

SN - 0355-3140

IS - 4

ER -