Attenuation correction using count-limited transmission data in positron emission tomography

S. R. Meikle, M. Dahlbom, Simon R Cherry

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Poisson noise in transmission data can have a significant influence on the statistical uncertainty of PET measurements, particularly at low transmission count rates. In this paper, we investigate the effect of transmission data processing on noise and quantitative accuracy of reconstructed PET images. Differences in spatial resolution between emission and transmission measurements due to transmission data smoothing are shown to have a significant influence on quantitative accuracy and can lead to artifacts in the reconstructed image. In addition, the noise suppression of this technique is insufficient to greatly reduce transmission scan times. Based on these findings, improved strategies for processing count-limited transmission data have been developed, including a method using segmentation of attenuation images. Using this method, accurate attenuation correction can be performed using transmission scan times as low as 2 min without increasing noise in reconstructed PET images.

Original languageEnglish (US)
Pages (from-to)143-144
Number of pages2
JournalJournal of Nuclear Medicine
Volume34
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Positron-Emission Tomography
Noise
Artifacts
Uncertainty

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Attenuation correction using count-limited transmission data in positron emission tomography. / Meikle, S. R.; Dahlbom, M.; Cherry, Simon R.

In: Journal of Nuclear Medicine, Vol. 34, No. 1, 1993, p. 143-144.

Research output: Contribution to journalArticle

@article{8f68ef2b25f94336981d315f0921f391,
title = "Attenuation correction using count-limited transmission data in positron emission tomography",
abstract = "Poisson noise in transmission data can have a significant influence on the statistical uncertainty of PET measurements, particularly at low transmission count rates. In this paper, we investigate the effect of transmission data processing on noise and quantitative accuracy of reconstructed PET images. Differences in spatial resolution between emission and transmission measurements due to transmission data smoothing are shown to have a significant influence on quantitative accuracy and can lead to artifacts in the reconstructed image. In addition, the noise suppression of this technique is insufficient to greatly reduce transmission scan times. Based on these findings, improved strategies for processing count-limited transmission data have been developed, including a method using segmentation of attenuation images. Using this method, accurate attenuation correction can be performed using transmission scan times as low as 2 min without increasing noise in reconstructed PET images.",
author = "Meikle, {S. R.} and M. Dahlbom and Cherry, {Simon R}",
year = "1993",
language = "English (US)",
volume = "34",
pages = "143--144",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "1",

}

TY - JOUR

T1 - Attenuation correction using count-limited transmission data in positron emission tomography

AU - Meikle, S. R.

AU - Dahlbom, M.

AU - Cherry, Simon R

PY - 1993

Y1 - 1993

N2 - Poisson noise in transmission data can have a significant influence on the statistical uncertainty of PET measurements, particularly at low transmission count rates. In this paper, we investigate the effect of transmission data processing on noise and quantitative accuracy of reconstructed PET images. Differences in spatial resolution between emission and transmission measurements due to transmission data smoothing are shown to have a significant influence on quantitative accuracy and can lead to artifacts in the reconstructed image. In addition, the noise suppression of this technique is insufficient to greatly reduce transmission scan times. Based on these findings, improved strategies for processing count-limited transmission data have been developed, including a method using segmentation of attenuation images. Using this method, accurate attenuation correction can be performed using transmission scan times as low as 2 min without increasing noise in reconstructed PET images.

AB - Poisson noise in transmission data can have a significant influence on the statistical uncertainty of PET measurements, particularly at low transmission count rates. In this paper, we investigate the effect of transmission data processing on noise and quantitative accuracy of reconstructed PET images. Differences in spatial resolution between emission and transmission measurements due to transmission data smoothing are shown to have a significant influence on quantitative accuracy and can lead to artifacts in the reconstructed image. In addition, the noise suppression of this technique is insufficient to greatly reduce transmission scan times. Based on these findings, improved strategies for processing count-limited transmission data have been developed, including a method using segmentation of attenuation images. Using this method, accurate attenuation correction can be performed using transmission scan times as low as 2 min without increasing noise in reconstructed PET images.

UR - http://www.scopus.com/inward/record.url?scp=0027391737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027391737&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 143

EP - 144

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 1

ER -