Attenuated poxvirus-based Simian Immunodeficiency Virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV

Koen K A Van Rompay, Kristina Abel, Jonathan R. Lawson, Raman P. Singh, Kimberli A. Schmidt, Thomas Evans, Patricia Earl, Danielle J Harvey, Genoveffa Franchini, James Tartaglia, David Montefiori, Shilpa Hattangadi, Bernard Moss, Marta Marthas

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

An infant macaque model was developed to test pediatric vaccine candidates aimed at reducing HIV transmission through breast-feeding. Infant macaques were given multiple immunizations during the first 3 weeks of life with recombinant poxvirus vaccines expressing simian immunodeficiency virus (SIV) structural proteins Gag, Pol, and Env (ALVAC-SIV or modified vaccinia virus Ankara [MVA]-SIV). After repeated daily oral inoculations with virulent SIVmac251 at 4 weeks of age, significantly fewer ALVAC-SIV-immunized infants were infected compared with unimmunized infants. Monkeys not infected after oral challenge in infancy were rechallenged at 16 months of age or older by repeated weekly oral SIV exposure; unimmunized animals were infected after fewer SIV exposures than were animals vaccinated with ALVAC-SIV or MVA-SIV. When infected, ALVAC-SIV- and MVA-SIV-vaccinated animals also had reduced viremia compared with unimmunized animals. The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding.

Original languageEnglish (US)
Pages (from-to)124-134
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2005

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Keywords

  • AIDS
  • Breast-feeding
  • HIV
  • Infant
  • Macaque
  • Pediatric
  • Poxvirus
  • Transmission
  • Vaccine

ASJC Scopus subject areas

  • Virology
  • Immunology

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