Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

Joel Stoddard; Tara A Niendam; Robert Hendren; Cameron S Carter; Tony J Simon

doi:10.1016/j.schres.2009.12.011

Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

Joel Stoddard, Tara A Niendam, Robert Hendren, Cameron S Carter, Tony J Simon

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.

Original language	English (US)
Pages (from-to)	118-121
Number of pages	4
Journal	Schizophrenia Research
Volume	118
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2009.12.011
State	Published - May 2010

Keywords

Chromosome 22q11.2 deletion syndrome
Clinical-high-risk psychosis
Prodromal psychosis
Schizophrenia
VCFS

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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AU - Carter, Cameron S

AU - Simon, Tony J

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Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

Abstract

Keywords

ASJC Scopus subject areas

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