Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

Joel Stoddard, Tara A Niendam, Robert Hendren, Cameron S Carter, Tony J Simon

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalSchizophrenia Research
Volume118
Issue number1-3
DOIs
StatePublished - May 2010

Fingerprint

Prodromal Symptoms
DiGeorge Syndrome
Chromosome Deletion
Psychotic Disorders
Interviews
Schizophrenia

Keywords

  • Chromosome 22q11.2 deletion syndrome
  • Clinical-high-risk psychosis
  • Prodromal psychosis
  • Schizophrenia
  • VCFS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. / Stoddard, Joel; Niendam, Tara A; Hendren, Robert; Carter, Cameron S; Simon, Tony J.

In: Schizophrenia Research, Vol. 118, No. 1-3, 05.2010, p. 118-121.

Research output: Contribution to journalArticle

@article{61263ba941fa467698a171791931f688,
title = "Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome",
abstract = "Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45{\%}) experienced positive symptoms rated in the {"}moderate{"} to {"}severe and psychotic{"} range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.",
keywords = "Chromosome 22q11.2 deletion syndrome, Clinical-high-risk psychosis, Prodromal psychosis, Schizophrenia, VCFS",
author = "Joel Stoddard and Niendam, {Tara A} and Robert Hendren and Carter, {Cameron S} and Simon, {Tony J}",
year = "2010",
month = "5",
doi = "10.1016/j.schres.2009.12.011",
language = "English (US)",
volume = "118",
pages = "118--121",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

AU - Stoddard, Joel

AU - Niendam, Tara A

AU - Hendren, Robert

AU - Carter, Cameron S

AU - Simon, Tony J

PY - 2010/5

Y1 - 2010/5

N2 - Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.

AB - Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.

KW - Chromosome 22q11.2 deletion syndrome

KW - Clinical-high-risk psychosis

KW - Prodromal psychosis

KW - Schizophrenia

KW - VCFS

UR - http://www.scopus.com/inward/record.url?scp=77951978706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951978706&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2009.12.011

DO - 10.1016/j.schres.2009.12.011

M3 - Article

C2 - 20056393

AN - SCOPUS:77951978706

VL - 118

SP - 118

EP - 121

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -