Abstract
Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-121 |
| Number of pages | 4 |
| Journal | Schizophrenia Research |
| Volume | 118 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - May 2010 |
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Keywords
- Chromosome 22q11.2 deletion syndrome
- Clinical-high-risk psychosis
- Prodromal psychosis
- Schizophrenia
- VCFS
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. / Stoddard, Joel; Niendam, Tara A; Hendren, Robert; Carter, Cameron S; Simon, Tony J.
In: Schizophrenia Research, Vol. 118, No. 1-3, 05.2010, p. 118-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome
AU - Stoddard, Joel
AU - Niendam, Tara A
AU - Hendren, Robert
AU - Carter, Cameron S
AU - Simon, Tony J
PY - 2010/5
Y1 - 2010/5
N2 - Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.
AB - Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1. years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the "moderate" to "severe and psychotic" range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains.
KW - Chromosome 22q11.2 deletion syndrome
KW - Clinical-high-risk psychosis
KW - Prodromal psychosis
KW - Schizophrenia
KW - VCFS
UR - http://www.scopus.com/inward/record.url?scp=77951978706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951978706&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2009.12.011
DO - 10.1016/j.schres.2009.12.011
M3 - Article
C2 - 20056393
AN - SCOPUS:77951978706
VL - 118
SP - 118
EP - 121
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -