Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer

Jianhong Qiu, Xiangwei Wang, Xiaodong Meng, Yan Zheng, Gang Li, Jiyao Ma, Gang Ye, Yong Li, Jie Li, Xinbin Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.

Original languageEnglish (US)
Article numbere115224
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 23 2014

Fingerprint

Urinary Bladder Neoplasms
Genes
Smoking
Recurrence
Defects
Tissue
immunochemistry
Immunochemistry
Gene Expression
gene expression
genes
Hazards
urinary bladder neoplasms
Messenger RNA
Real-Time Polymerase Chain Reaction
quantitative polymerase chain reaction
risk factors
neoplasms
Survival
Proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer. / Qiu, Jianhong; Wang, Xiangwei; Meng, Xiaodong; Zheng, Yan; Li, Gang; Ma, Jiyao; Ye, Gang; Li, Yong; Li, Jie; Chen, Xinbin.

In: PLoS One, Vol. 9, No. 12, e115224, 23.12.2014.

Research output: Contribution to journalArticle

Qiu, Jianhong ; Wang, Xiangwei ; Meng, Xiaodong ; Zheng, Yan ; Li, Gang ; Ma, Jiyao ; Ye, Gang ; Li, Yong ; Li, Jie ; Chen, Xinbin. / Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer. In: PLoS One. 2014 ; Vol. 9, No. 12.
@article{e04da5a4cf3a4a1388252a9514b149b9,
title = "Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer",
abstract = "The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.",
author = "Jianhong Qiu and Xiangwei Wang and Xiaodong Meng and Yan Zheng and Gang Li and Jiyao Ma and Gang Ye and Yong Li and Jie Li and Xinbin Chen",
year = "2014",
month = "12",
day = "23",
doi = "10.1371/journal.pone.0115224",
language = "English (US)",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer

AU - Qiu, Jianhong

AU - Wang, Xiangwei

AU - Meng, Xiaodong

AU - Zheng, Yan

AU - Li, Gang

AU - Ma, Jiyao

AU - Ye, Gang

AU - Li, Yong

AU - Li, Jie

AU - Chen, Xinbin

PY - 2014/12/23

Y1 - 2014/12/23

N2 - The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.

AB - The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.

UR - http://www.scopus.com/inward/record.url?scp=84919798333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919798333&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0115224

DO - 10.1371/journal.pone.0115224

M3 - Article

C2 - 25535740

AN - SCOPUS:84919798333

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e115224

ER -