Abstract
The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.
| Original language | English (US) |
|---|---|
| Article number | e115224 |
| Journal | PLoS One |
| Volume | 9 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 23 2014 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer. / Qiu, Jianhong; Wang, Xiangwei; Meng, Xiaodong; Zheng, Yan; Li, Gang; Ma, Jiyao; Ye, Gang; Li, Yong; Li, Jie; Chen, Xinbin.
In: PLoS One, Vol. 9, No. 12, e115224, 23.12.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer
AU - Qiu, Jianhong
AU - Wang, Xiangwei
AU - Meng, Xiaodong
AU - Zheng, Yan
AU - Li, Gang
AU - Ma, Jiyao
AU - Ye, Gang
AU - Li, Yong
AU - Li, Jie
AU - Chen, Xinbin
PY - 2014/12/23
Y1 - 2014/12/23
N2 - The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.
AB - The varied NER genes and smoking are two important risk factors of bladder cancer, but the mechanism of the NER protein and smoking in cancer progression, however, remains unclear. In this report, we compared the expressions of NER genes in 79 bladder cancer tissues with or without any recurrence by real-time PCR and then analyzed the varied NER genes by immunochemistry in 219 bladder cancer tissue samples. Based on the clinical data, we analyzed the clinical value of varied NER genes and smoking in 219 bladder cancers by the Kaplan-Meier method and Cox proportional hazards regression. We found the expressions of the NER gene XPF and XPC were significantly lower in bladder cancer tissues with a recurrence compared with those without a recurrence at mRNA level. Also, the patients with the XPF and XPC defect had a statistically significant lower median recurrence-free survival time than those without the XPF and XPC defect, and smoking can make this difference more remarkable. Our results suggest that XPF and XPC expression may be a potential predictive factor for bladder cancer, and smoking can not only influence the recurrence of bladder cancer as a single factor but also aggravate the results of the XPF defect and XPC defect.
UR - http://www.scopus.com/inward/record.url?scp=84919798333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919798333&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0115224
DO - 10.1371/journal.pone.0115224
M3 - Article
C2 - 25535740
AN - SCOPUS:84919798333
VL - 9
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
M1 - e115224
ER -