Attention bias to threat faces in severe mood dysregulation

Rebecca E. Hommer, Allison Meyer, Joel Stoddard, Megan E. Connolly, Karin Mogg, Brendan P. Bradley, Daniel S. Pine, Ellen Leibenluft, Melissa A. Brotman

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency to allocate attention to threat is well established in anxiety and other disorders of negative affect. SMD is characterized by the negative affect of irritability, and longitudinal studies suggest childhood irritability predicts adult anxiety and depression. Therefore, it is important to study pathophysiologic connections between irritability and anxiety disorders. Methods SMD patients (N = 74) and HC youth (N = 42) completed a visual probe paradigm to assess attention bias to emotional faces. Diagnostic interviews were conducted and measures of irritability and anxiety were obtained in patients. Results SMD youth differed from HC youth in having a bias toward threatening faces (P <.01). Threat bias was positively correlated with the severity of the SMD syndrome and depressive symptoms; degree of threat bias did not differ between SMD youth with and without co-occurring anxiety disorders or depression. SMD and HC youth did not differ in bias toward or away from happy faces. Conclusions SMD youth demonstrate an attention bias toward threat, with greater threat bias associated with higher levels of SMD symptom severity. Our findings suggest that irritability may share a pathophysiological link with anxiety and depressive disorders. This finding suggests the value of exploring further whether attention bias modification treatments that are effective for anxiety are also helpful in the treatment of irritability.

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalDepression and Anxiety
Issue number7
StatePublished - 2014
Externally publishedYes


  • anxiety
  • biological markers
  • child and adolescent
  • cognition
  • mood disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology


Dive into the research topics of 'Attention bias to threat faces in severe mood dysregulation'. Together they form a unique fingerprint.

Cite this