Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not

Carl R. Lupica, Robert F Berman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The development of kindled seizures elicited through electrical stimulation of the rat olfactory bulb (OB) was examined under two conditions which decrease cholinergic neurotransmission. Atropine sulfate (25 mg/kg, IP) administered 1 hr prior to stimulation of the OB was found to significantly delay the acquisition of the fully kindled state. In a second experiment, diminished cholinergic innervation of the OB was established using chemical lesions of the basal forebrain cholinergic system. Despite the depletion of acetylcholine (Ach), as determined by acetylcholinesterase (AchE) and choline acetyltransferase (ChAt) assays, no significant alterations in kindling parameters were observed. Based upon these findings we suggest that Ach is not critical to the establishment of an OB kindled focus but is important for the propogation and generalization of epileptiform activity initiated through OB stimulation.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalBrain Research Bulletin
Volume20
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • Acetylcholine
  • Acetylcholinesterase
  • Basal forebrain
  • Choline acetyltransferase
  • Kindling
  • Olfactory bulb
  • Scizures

ASJC Scopus subject areas

  • Neuroscience(all)

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