Atrial natriuretic peptide: An essential physiological regulator of transvascular fluid, protein transport, and plasma volume

Fitz Roy E Curry

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability. Authors of a study in this issue of the JCI performed a knockout of the receptor for ANP in vascular endothelia in order to distinguish the effects of ANP-dependent increases in vascular permeability from those of other endocrine actions of ANP in the regulation of plasma volume. The knockout mice exhibited reduced vascular permeability to plasma protein, resulting in chronically increased plasma volume, arterial hypertension, and cardiac hypertrophy. Renal excretion and vasodilation did not account for these changes. Thus ANP-induced increases in endothelial permeability may be critical to the ability of ANP to lower arterial blood pressure.

Original languageEnglish (US)
Pages (from-to)1458-1461
Number of pages4
JournalJournal of Clinical Investigation
Volume115
Issue number6
DOIs
StatePublished - Jun 2005

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Plasma Volume
Atrial Natriuretic Factor
Protein Transport
Capillary Permeability
Vasodilation
Atrial Natriuretic Factor Receptors
Vascular Endothelium
Cardiomegaly
Knockout Mice
Blood Proteins
Permeability
Arterial Pressure
Salts
Hypertension
Water
Renal Elimination

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Atrial natriuretic peptide : An essential physiological regulator of transvascular fluid, protein transport, and plasma volume. / Curry, Fitz Roy E.

In: Journal of Clinical Investigation, Vol. 115, No. 6, 06.2005, p. 1458-1461.

Research output: Contribution to journalArticle

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